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    Trf4-1 Topoisomerase related function 4-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trf4-1provided by FlyBase
    Official Full Name
    Topoisomerase related function 4-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030049
    Locus tag
    Dmel_CG11265
    See related
    AllianceGenome:FB:FBgn0030049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF46390; CG11265; Dmel\CG11265; DmTRF4-1; dTrf4-1; Trf4
    Summary
    Enables poly(A) RNA polymerase activity. Involved in polyadenylation-dependent ncRNA catabolic process. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in spermatozoon. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A) and TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trf4-1 in Genome Data Viewer
    Location:
    7F4-7F4; 1-23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8560322..8570159)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8454355..8464192)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Integrator 4 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46195 Neighboring gene uncharacterized protein Neighboring gene Serine Protease Immune Response Integrator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligoadenylation of 3' decay intermediates promotes cytoplasmic mRNA degradation in Drosophila cells. Harnisch C, et al. RNA, 2016 Mar. PMID 26786835, Free PMC Article
    2. The incorporation of 5-fluorouracil into RNA affects the ribonucleolytic activity of the exosome subunit Rrp6. Silverstein RA, et al. Mol Cancer Res, 2011 Mar. PMID 21289297
    3. Local dynamics of a fast-evolving sex-ratio system in Drosophila simulans. Bastide H, et al. Mol Ecol, 2013 Nov. PMID 24118375
    4. Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Modepalli V, et al. Genome Biol Evol, 2017 Jun 1. PMID 28633361, Free PMC Article
    5. Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila. Witsell A, et al. Genetics, 2009 Nov. PMID 19687136, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    topoisomerase related function 4-1
    Names
    CG11265-PC
    CG11265-PE
    CG11265-PF
    CG11265-PG
    CG11265-PH
    CG11265-PI
    CG11265-PJ
    Trf4-1-PC
    Trf4-1-PE
    Trf4-1-PF
    Trf4-1-PG
    Trf4-1-PH
    Trf4-1-PI
    Trf4-1-PJ
    NP_001096913.1
    NP_001096914.1
    NP_001259340.1
    NP_572490.2
    NP_996381.1
    NP_996382.2
    NP_996383.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8560322..8570159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206658.4 → NP_996381.1  topoisomerase related function 4-1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV36, Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:291 → 401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:458 → 518
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_132262.3 → NP_572490.2  topoisomerase related function 4-1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572490.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV36, Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:291 → 401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:458 → 518
      PAP_assoc; Cid1 family poly A polymerase

    3. NM_001103443.2 → NP_001096913.1  topoisomerase related function 4-1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:92 → 202
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:259 → 319
      PAP_assoc; Cid1 family poly A polymerase

    4. NM_001272411.1 → NP_001259340.1  topoisomerase related function 4-1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV36, Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:291 → 401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:458 → 518
      PAP_assoc; Cid1 family poly A polymerase

    5. NM_001103444.2 → NP_001096914.1  topoisomerase related function 4-1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:92 → 202
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:259 → 319
      PAP_assoc; Cid1 family poly A polymerase

    6. NM_206659.3 → NP_996382.2  topoisomerase related function 4-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996382.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV36, Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:291 → 401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:458 → 518
      PAP_assoc; Cid1 family poly A polymerase

    7. NM_206660.2 → NP_996383.2  topoisomerase related function 4-1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996383.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV36, Q7KVS9
      Conserved Domains (2) summary
      cd05402
      Location:291 → 401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:458 → 518
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVS9.1 Q7KVS9

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