U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trxr2 Thioredoxin reductase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40475, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Trxr2provided by FlyBase
    Official Full Name
    Thioredoxin reductase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037170
    Locus tag
    Dmel_CG11401
    See related
    AllianceGenome:FB:FBgn0037170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11401; Dm-TrxR; Dmel\CG11401; DmTrx; DmTrxR; DmTrxR-2; TRR; TrxR; trxr-2; Trxr-2
    Summary
    Enables thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be active in cytosol and mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human TXNRD2 (thioredoxin reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Trxr2 in Genome Data Viewer
    Location:
    79E8-79E8; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22550226..22552019)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22543326..22545119)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mir-957 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46348 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Active sites of thioredoxin reductases: why selenoproteins? Gromer S, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14569031, Free PMC Article
    2. Identification and conformer analysis of a novel redox-active motif, Pro-Ala-Ser-Cys-Cys-Ser, in Drosophila thioredoxin reductase by semiempirical molecular orbital calculation. Kuwahara M, et al. Biosci Biotechnol Biochem, 2011. PMID 21389620
    3. Glutathionylation of trypanosomal thiol redox proteins. Melchers J, et al. J Biol Chem, 2007 Mar 23. PMID 17242409
    4. Gain of function conferred by selenocysteine: catalytic enhancement of one-electron transfer reactions by thioredoxin reductase. Barber DR, et al. Protein Sci, 2019 Jan. PMID 30052295, Free PMC Article
    5. Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. Pickering AM, et al. Aging Cell, 2017 Aug. PMID 28474396, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mitochondrial and cytoplasmic variants are both essential for viability
      Title: Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    thioredoxin reductase 2
    Names
    CG11401-PA
    Trxr2-PA
    thioredoxin reductase
    thioredoxin-reductase-2
    NP_524216.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22550226..22552019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079492.3 → NP_524216.1  thioredoxin reductase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VNT5
      Related
      FBpp0078166
      Conserved Domains (4) summary
      TIGR01438
      Location:31 → 515
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:214 → 288
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:388 → 497
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:29 → 68
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNT5.1 Q9VNT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools