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    Tbc1d15-17 TBC1 domain family member 15/17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d15-17provided by FlyBase
    Official Full Name
    TBC1 domain family member 15/17provided by FlyBase
    Primary source
    FLYBASE:FBgn0031233
    Locus tag
    Dmel_CG11490
    See related
    AllianceGenome:FB:FBgn0031233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11490; Dmel\CG11490
    Summary
    Enables small GTPase binding activity. Is expressed in embryonic/larval midgut and organism. Orthologous to human TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tbc1d15-17 in Genome Data Viewer
    Location:
    21B4-21B4; 2-0.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (207179..210725)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (207179..210725)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene split ends Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene long non-coding RNA:CR44220 Neighboring gene long non-coding RNA:CR44222 Neighboring gene kismet

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tbc1d15-17 regulates synaptic development at the Drosophila neuromuscular junction. Lee MJ, et al. Mol Cells, 2013 Aug. PMID 23812537, Free PMC Article
    2. Rab11 regulates cell-cell communication during collective cell movements. Ramel D, et al. Nat Cell Biol, 2013 Mar. PMID 23376974, Free PMC Article
    3. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    4. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    5. Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes. Yu Y, et al. PLoS Genet, 2024 Feb. PMID 38315726, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show novel role for Tbc1d15-17 and its potential substrate Rab7 in regulating synaptic development.
      Title: Tbc1d15-17 regulates synaptic development at the Drosophila neuromuscular junction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBC1 domain family member 15/17
    Names
    CG11490-PA
    CG11490-PB
    CG11490-PC
    TBC1 domain family, member 15/17 ortholog
    Tbc1d15-17-PA
    Tbc1d15-17-PB
    Tbc1d15-17-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      207179..210725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272877.1 → NP_001259806.1  TBC1 domain family member 15/17, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPL5
      Conserved Domains (2) summary
      pfam12068
      Location:37 → 191
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:369 → 598
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001272878.1 → NP_001259807.1  TBC1 domain family member 15/17, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPL5
      Conserved Domains (2) summary
      pfam12068
      Location:37 → 191
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:369 → 598
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. NM_134659.4 → NP_608503.1  TBC1 domain family member 15/17, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPL5
      Related
      FBpp0077784
      Conserved Domains (2) summary
      pfam12068
      Location:37 → 191
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:369 → 598
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPL5 Q9VPL5

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