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    ttk tramtrack [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48317, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ttkprovided by FlyBase
    Official Full Name
    tramtrackprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003870
    Locus tag
    Dmel_CG1856
    See related
    AllianceGenome:FB:FBgn0003870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0037/17; 0250/25; 0438/31; 0702/07; 1049/07; 1119/04; 1184/16; 1209/05; 1209/10; 1260/10; 1281/04; 1325/15; 1372/08; 1396/14; 1418/06; 3540; 5125; 5311; anon-EST:Liang-2.9; CG11558; CG1856; clone 2.9; Dmel\CG1856; E(yan)100D; ftz-f2; FTZ-F2; ftzf2/ttk; l(3)02667; l(3)j2A1; l(3)j7B8; osn; oss; ovs; Tkt69; Tramtrack; tramtrak; Ttk; TTK; ttk/FTZ-F2; ttk69; Ttk69; TTK69; Ttk69k; Ttk88; TTK88; TTKA; ttkp69
    Summary
    Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including compound eye morphogenesis; egg chorion assembly; and open tracheal system development. Located in nucleus and polytene chromosome. Part of transcription repressor complex. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial cell; germ layer; gut section; and pigment cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ttk in Genome Data Viewer
    Location:
    100D1-100D1; 3-102 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31713867..31735392)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27539589..27561114)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34046 Neighboring gene uncharacterized protein Neighboring gene Cleavage stimulation factor 50 kD subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages. Cumley NJ, et al. Infect Immun, 2012 May. PMID 22331428, Free PMC Article
    2. Sequence-specific DNA binding by a two zinc-finger peptide from the Drosophila melanogaster Tramtrack protein. Fairall L, et al. J Mol Biol, 1992 Jul 20. PMID 1640455
    3. Modulation of DNA binding of a tramtrack zinc finger peptide by the metallothionein-thionein conjugate pair. Roesijadi G, et al. J Biol Chem, 1998 Jul 10. PMID 9651329
    4. Structural analysis of zinc-finger (TTK) + [Cu(BPA)]2+ /[Cu(IDB)]2+ + DNA complexes: an investigation by molecular dynamics simulation. Wang Y, et al. J Mol Recognit, 2011 Nov-Dec. PMID 22038805
    5. The cocrystal structures of two zinc-stabilized DNA-binding domains illustrate different ways of achieving sequence-specific DNA recognition. Schwabe JW, et al. Cold Spring Harb Symp Quant Biol, 1993. PMID 7956024

    See all (418) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster.
      Title: TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster.
    2. Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.
      Title: Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.
    3. Ttk69 plays a central role in shaping neural cell lineages . Ttk69 (1) promotes cell cycle exit of neural stem cells by downregulating CycE, and (2) regulates cell-fate acquisition and terminal differentiation, by downregulating the expression of hamlet and upregulating that of Suppressor of Hairless.
      Title: Shaping of Drosophila Neural Cell Lineages Through Coordination of Cell Proliferation and Cell Fate by the BTB-ZF Transcription Factor Tramtrack-69.
    4. Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A
      Title: Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation.
    5. N activity is required to promote dpn transcription; only in R7 photoreceptor precursors does the removal of Ttk coincide with high N activity; and only in this cell does Dpn expression result
      Title: R7 Photoreceptor Specification in the Developing Drosophila Eye: The Role of the Transcription Factor Deadpan.
    6. Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.
      Title: Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.
    7. The presence and timing of ttk69 expression are essential for somatic muscle development and required for the balance between founder cells and fusion-competent myoblasts.
      Title: Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis.
    8. Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.
      Title: Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
    9. Tramtrack69 functions as a developmental switch in Drosophila follicle cells where it is regulated by miR-7.
      Title: The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells.
    10. Ttk69 plays an instructive role in the growth of R7 photoreceptor axon terminals
      Title: R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-β/activin signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables POZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R1/R6 development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye cone cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye corneal lens morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal trunk growth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in enteroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of compound eye cone cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of compound eye cone cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tramtrack
    Names
    CG1856-PA
    CG1856-PB
    CG1856-PC
    CG1856-PD
    CG1856-PE
    CG1856-PF
    CG1856-PG
    CG1856-PH
    Tramtrack69
    Tramtrack88
    Ttk88 repressor
    enhancer of yan at 100D
    oversensitive
    schmal
    tramtrack-69
    tramtrak
    ttk-PA
    ttk-PB
    ttk-PC
    ttk-PD
    ttk-PE
    ttk-PF
    ttk-PG
    ttk-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31713867..31735392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170566.3 → NP_733445.1  tramtrack, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q3, P42282, Q0KHY0, Q1LZ43, Q24313, Q9V9V2
      UniProtKB/TrEMBL
      A0A0B4JDG1
      Related
      FBpp0085186
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:612 → 638
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam13894
      Location:646 → 669
      zf-C2H2_4; C2H2-type zinc finger

    2. NM_170568.3 → NP_733447.1  tramtrack, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q4, P17789, Q32KE0, Q9V9V1, Q9V9V3
      UniProtKB/TrEMBL
      A0A0B4JD39
      Related
      FBpp0085187
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:510 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam05605
      Location:507 → 561
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    3. NM_170565.2 → NP_733444.1  tramtrack, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q3, P42282, Q0KHY0, Q1LZ43, Q24313, Q9V9V2
      UniProtKB/TrEMBL
      A0A0B4JDG1
      Related
      FBpp0085188
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:612 → 638
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam13894
      Location:646 → 669
      zf-C2H2_4; C2H2-type zinc finger

    4. NM_080172.4 → NP_524911.3  tramtrack, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524911.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q4, P17789, Q32KE0, Q9V9V1, Q9V9V3
      UniProtKB/TrEMBL
      A0A0B4JD39
      Related
      FBpp0085189
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:510 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam05605
      Location:507 → 561
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    5. NM_170564.3 → NP_733443.1  tramtrack, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733443.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q3, P42282, Q0KHY0, Q1LZ43, Q24313, Q9V9V2
      UniProtKB/TrEMBL
      A0A0B4JDG1
      Related
      FBpp0085190
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:612 → 638
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam13894
      Location:646 → 669
      zf-C2H2_4; C2H2-type zinc finger

    6. NM_170567.3 → NP_733446.1  tramtrack, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733446.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q4, P17789, Q32KE0, Q9V9V1, Q9V9V3
      UniProtKB/TrEMBL
      A0A0B4JD39
      Related
      FBpp0085191
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:510 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam05605
      Location:507 → 561
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    7. NM_001202400.1 → NP_001189329.1  tramtrack, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q3, P42282, Q0KHY0, Q1LZ43, Q24313, Q9V9V2
      UniProtKB/TrEMBL
      A0A0B4JDG1
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:612 → 638
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam13894
      Location:646 → 669
      zf-C2H2_4; C2H2-type zinc finger

    8. NM_001202401.1 → NP_001189330.1  tramtrack, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189330.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Q4, P17789, Q32KE0, Q9V9V1, Q9V9V3
      UniProtKB/TrEMBL
      A0A0B4JD39
      Conserved Domains (4) summary
      smart00225
      Location:34 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:510 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:23 → 119
      BTB; BTB/POZ domain
      pfam05605
      Location:507 → 561
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD39 A0A0B4JD39
    A0A0B4JDG1 A0A0B4JDG1
    P17789.2 P17789
    P42282.3 P42282
    Q8T3M3 Q8T3M3

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