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    Acsx1R Acyl-CoA synthetase X1 R [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsx1Rprovided by FlyBase
    Official Full Name
    Acyl-CoA synthetase X1 Rprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038731
    Locus tag
    Dmel_CG11659
    See related
    AllianceGenome:FB:FBgn0038731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11659; Dmel\CG11659
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic hindgut; embryonic precursor of adult hindgut; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Acsx1R in Genome Data Viewer
    Location:
    92B2-92B2; 3-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19775459..19777280, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15601181..15603002, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutamate-gated chloride channel subunit alpha Neighboring gene long non-coding RNA:CR43488 Neighboring gene Acyl-CoA synthetase X1 L Neighboring gene Acyl-CoA synthetase X2 Neighboring gene Acyl-CoA synthetase X3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number. Loehlin DW, et al. Genetics, 2022 Mar 3. PMID 35100388, Free PMC Article
    2. The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. King-Jones K, et al. Cell Metab, 2006 Jul. PMID 16814731
    3. A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila. Okamoto N, et al. Dev Cell, 2018 Nov 5. PMID 30293839, Free PMC Article
    4. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
    5. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA synthetase X1 R
    Names
    Acsx1R-PA
    CG11659-PA
    NP_650829.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19775459..19777280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142572.2 → NP_650829.1  Acyl-CoA synthetase X1 R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDU3
      Related
      FBpp0083208
      Conserved Domains (2) summary
      COG0318
      Location:26 → 523
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      cl17068
      Location:47 → 522
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDU3 Q9VDU3

    Gene LinkOut

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