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    Cmklr1 chemerin chemokine-like receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14747, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cmklr1provided by MGI
    Official Full Name
    chemerin chemokine-like receptor 1provided by MGI
    Primary source
    MGI:MGI:109603
    See related
    Ensembl:ENSMUSG00000042190 AllianceGenome:MGI:109603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DEZ; Gpcr27; ChemR23; mcmklr1
    Summary
    Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 58.5), subcutaneous fat pad adult (RPKM 38.4) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cmklr1 in Genome Data Viewer
    Location:
    5 F; 5 55.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113750415..113792971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113612355..113650475, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30812 Neighboring gene WSC domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_14042 Neighboring gene predicted gene, 52822 Neighboring gene STARR-seq mESC enhancer starr_14044 Neighboring gene STARR-seq mESC enhancer starr_14048 Neighboring gene STARR-seq mESC enhancer starr_14049 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adipokinetic hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adipokinetic hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adipokinetic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    chemerin-like receptor 1
    Names
    G-protein coupled receptor 27
    G-protein coupled receptor DEZ
    chemerin receptor
    chemokine receptor-like 1
    chemokine-like receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359060.1NP_001345989.1  chemerin-like receptor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC241893, CJ072893
      Consensus CDS
      CCDS19551.1
      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_008153.3NP_032179.1  chemerin-like receptor 1

      See identical proteins and their annotated locations for NP_032179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC241893, BY347978
      Consensus CDS
      CCDS19551.1
      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Related
      ENSMUSP00000036316.7, ENSMUST00000047936.13
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113750415..113792971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164795.1XP_036020688.1  chemerin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006530164.5XP_006530227.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530227.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_006530166.3XP_006530229.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530229.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Related
      ENSMUSP00000121765.2, ENSMUST00000132065.8
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_006530165.4XP_006530228.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530228.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors