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    Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20525, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc2a1provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 1provided by MGI
    Primary source
    MGI:MGI:95755
    See related
    Ensembl:ENSMUSG00000028645 AllianceGenome:MGI:95755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GT1; Glut1; Glut-1; M100200; Rgsc200
    Summary
    Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and fucose transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Acts upstream of or within cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; nucleus; and photoreceptor inner segment. Is active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 161.1), placenta adult (RPKM 140.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc2a1 in Genome Data Viewer
    Location:
    4 D2.1; 4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118966001..118994527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119108745..119137330)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11219 Neighboring gene predicted gene, 35510 Neighboring gene STARR-seq mESC enhancer starr_11222 Neighboring gene STARR-positive B cell enhancer ABC_E6204 Neighboring gene predicted gene, 52706 Neighboring gene STARR-positive B cell enhancer ABC_E3506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118781841-118782024 Neighboring gene STARR-seq mESC enhancer starr_11226 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118800270-118800453 Neighboring gene predicted gene 12867 Neighboring gene STARR-positive B cell enhancer ABC_E422 Neighboring gene zinc finger protein 691 Neighboring gene erythroblast membrane-associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dehydroascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dehydroascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-glucose import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in D-glucose import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hyperosmotic response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dehydroascorbic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dehydroascorbic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in photoreceptor cell maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to Thyroglobulin triiodothyronine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport across blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of glucose transporter complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 1
    Names
    glucose transporter type 1, erythrocyte/brain
    solute carrier family 2, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424864.1NP_001411793.1  solute carrier family 2, facilitated glucose transporter member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606975
      UniProtKB/TrEMBL
      Q3TD17
    2. NM_011400.4NP_035530.2  solute carrier family 2, facilitated glucose transporter member 1 isoform 1

      See identical proteins and their annotated locations for NP_035530.2

      Status: VALIDATED

      Source sequence(s)
      AL606975
      Consensus CDS
      CCDS18569.1
      UniProtKB/Swiss-Prot
      P17809, Q61608, Q6GTI3
      UniProtKB/TrEMBL
      Q3TD17
      Related
      ENSMUSP00000030398.4, ENSMUST00000030398.10
      Conserved Domains (2) summary
      cd06174
      Location:62450
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:19467
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      118966001..118994527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)