Klhdc10 kelch domain containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhdc10provided by MGI
Official Full Name: kelch domain containing 10provided by MGI
Primary source: MGI:MGI:1924038
See related: Ensembl:ENSMUSG00000029775 AllianceGenome:MGI:1924038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0265; 2410127E18Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade; rescue of stalled ribosome; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 31.1), whole brain E14.5 (RPKM 31.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.52 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (30401516..30455178)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (30401517..30455179)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that KLHDC10 is a cell-type specific regulator of necroptosis that ultimately contributes to the development of TNFalpha-induced SIRS
Title: KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI593221 (e-PCR)
- UniSTS:165456

NoName (e-PCR)
- UniSTS:235395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311087.1 → NP_001298016.1 kelch domain-containing protein 10 isoform 2

See identical proteins and their annotated locations for NP_001298016.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AK085116, BC056496, CJ134796

Consensus CDS

CCDS80509.1

UniProtKB/Swiss-Prot

Q6PAR0

Related

ENSMUSP00000064594.7, ENSMUST00000068240.13

Conserved Domains (4) summary

PLN02153
Location:107 → 270

PLN02153; epithiospecifier protein

PRK14131
Location:56 → 139

PRK14131; N-acetylneuraminate epimerase

sd00038
Location:176 → 224

Kelch; KELCH repeat [structural motif]

pfam01344
Location:283 → 329

Kelch_1; Kelch motif
NM_029742.3 → NP_084018.1 kelch domain-containing protein 10 isoform 1

See identical proteins and their annotated locations for NP_084018.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC056496, BC060132, CJ134796

Consensus CDS

CCDS19971.1

UniProtKB/Swiss-Prot

Q6A095, Q6PAR0, Q8BH94, Q8BPK7, Q8C3Q4, Q8C7G4, Q9CWF4

Related

ENSMUSP00000069669.7, ENSMUST00000068259.10

Conserved Domains (4) summary

PLN02153
Location:136 → 299

PLN02153; epithiospecifier protein

PRK14131
Location:85 → 168

PRK14131; N-acetylneuraminate epimerase

sd00038
Location:205 → 253

Kelch; KELCH repeat [structural motif]

pfam01344
Location:312 → 358

Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

30401516..30455178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255666.1 → XP_030111526.1 kelch domain-containing protein 10 isoform X2

Conserved Domains (2) summary

PLN02153
Location:40 → 201

PLN02153; epithiospecifier protein

sd00038
Location:54 → 100

Kelch; KELCH repeat [structural motif]
XM_017321829.2 → XP_017177318.1 kelch domain-containing protein 10 isoform X1

Conserved Domains (4) summary

PLN02153
Location:132 → 295

PLN02153; epithiospecifier protein

PRK14131
Location:81 → 164

PRK14131; N-acetylneuraminate epimerase

sd00038
Location:201 → 249

Kelch; KELCH repeat [structural motif]

pfam01344
Location:308 → 354

Kelch_1; Kelch motif