U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prx6b Peroxiredoxin 6b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246663, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    Prx6bprovided by FlyBase
    Official Full Name
    Peroxiredoxin 6bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033520
    Locus tag
    Dmel_CG12405
    See related
    AllianceGenome:FB:FBgn0033520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1-cys peroxiredoxin DPx- 2540-1; BEST:LD11278; CG12405; Dmel\CG12405; dPRDX6-2; dPrx6a; DPx-2540-1; DPx2540; Prx2540; Prx2540-1
    Summary
    Enables peroxiredoxin activity. Involved in hydrogen peroxide catabolic process. Located in cytosol. Is expressed in adult head and organism. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prx6b in Genome Data Viewer
    Location:
    47A7-47A7; 2-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10424436..10425471)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6311941..6312976)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin 6c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ran-binding protein M

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. Li D, et al. J Insect Physiol, 2003 Jan. PMID 12770011
    2. The peroxiredoxin gene family in Drosophila melanogaster. Radyuk SN, et al. Free Radic Biol Med, 2001 Nov 1. PMID 11677042
    3. Beyond ROS clearance: Peroxiredoxins in stress signaling and aging. Detienne G, et al. Ageing Res Rev, 2018 Jul. PMID 29580920
    4. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Peterson TM, et al. Free Radic Biol Med, 2006 Mar 15. PMID 16540402, Free PMC Article
    5. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    peroxiredoxin 6b
    Names
    AOP2-related
    CG12405-PA
    Prx6b-PA
    peroxiredoxin 2540
    peroxiredoxin 2540-1
    NP_724931.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10424436..10425471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165769.1 → NP_724931.1  peroxiredoxin 6b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z892, Q9GPQ1
      Related
      FBpp0087356, FBtr0088261
      Conserved Domains (2) summary
      COG0450
      Location:1 → 194
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03016
      Location:3 → 218
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z892 A1Z892
    Q9GPQ1 Q9GPQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools