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    Alcam activated leukocyte cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 11658, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alcamprovided by MGI
    Official Full Name
    activated leukocyte cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:1313266
    See related
    Ensembl:ENSMUSG00000022636 AllianceGenome:MGI:1313266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BEN; SC1; MuSC; CD166; DM-GRASP
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within motor neuron axon guidance. Located in axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart and pericardium; and sensory organ. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 24.3), CNS E11.5 (RPKM 16.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Alcam in Genome Data Viewer
    Location:
    16 B5; 16 32.88 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (52069359..52273444, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (52248996..52453081, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2463 Neighboring gene STARR-positive B cell enhancer ABC_E7459 Neighboring gene predicted gene, 29686 Neighboring gene STARR-positive B cell enhancer ABC_E5546 Neighboring gene STARR-seq mESC enhancer starr_41007 Neighboring gene Casitas B-lineage lymphoma b Neighboring gene STARR-seq mESC enhancer starr_41008 Neighboring gene STARR-positive B cell enhancer mm9_chr16:52149538-52149839 Neighboring gene predicted gene, 23513 Neighboring gene STARR-positive B cell enhancer mm9_chr16:52182153-52182454 Neighboring gene STARR-positive B cell enhancer ABC_E10910 Neighboring gene predicted gene, 32597 Neighboring gene predicted gene, 41461 Neighboring gene STARR-positive B cell enhancer ABC_E5547 Neighboring gene STARR-positive B cell enhancer ABC_E7461 Neighboring gene STARR-seq mESC enhancer starr_41009 Neighboring gene STARR-positive B cell enhancer ABC_E4178 Neighboring gene STARR-positive B cell enhancer ABC_E2464 Neighboring gene STARR-seq mESC enhancer starr_41011 Neighboring gene predicted gene, 52279 Neighboring gene STARR-seq mESC enhancer starr_41012 Neighboring gene RIKEN cDNA 4930404A05 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC27910

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of T cell receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331110.1NP_001318039.1  CD166 antigen isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC117780, AC154383, BE654940
      Consensus CDS
      CCDS84242.1
      UniProtKB/TrEMBL
      E9Q3Q6, E9Q4G8
      Related
      ENSMUSP00000129714.2, ENSMUST00000170035.8
    2. NM_009655.3NP_033785.1  CD166 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_033785.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154383, AK031391, AK161090, BE654940
      Consensus CDS
      CCDS37356.1
      UniProtKB/Swiss-Prot
      O70136, Q61490, Q8CDA5, Q8R2T0
      UniProtKB/TrEMBL
      E9Q4G8, Q54AJ5
      Related
      ENSMUSP00000023312.8, ENSMUST00000023312.14
      Conserved Domains (4) summary
      smart00410
      Location:255329
      IG_like; Immunoglobulin like
      pfam08205
      Location:137231
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:256313
      Ig_3; Immunoglobulin domain
      cl11960
      Location:415488
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      52069359..52273444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)