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    Odc1 ornithine decarboxylase, structural 1 [ Mus musculus (house mouse) ]

    Gene ID: 18263, updated on 3-Dec-2024

    Summary

    Official Symbol
    Odc1provided by MGI
    Official Full Name
    ornithine decarboxylase, structural 1provided by MGI
    Primary source
    MGI:MGI:97402
    See related
    Ensembl:ENSMUSG00000011179 AllianceGenome:MGI:97402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ODC
    Summary
    Enables ornithine decarboxylase activity and protein homodimerization activity. Involved in putrescine biosynthetic process from ornithine and regulation of protein catabolic process. Acts upstream of or within kidney development and positive regulation of cell population proliferation. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Used to study atrichia with papular lesions. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 226.2), liver E14.5 (RPKM 221.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Odc1 in Genome Data Viewer
    Location:
    12 A1.1- A1.2; 12 8.11 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17594906..17601503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17544808..17551502)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36752 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17460788-17461088 Neighboring gene STARR-seq mESC enhancer starr_31660 Neighboring gene STARR-seq mESC enhancer starr_31661 Neighboring gene predicted gene, 46325 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17513963-17514264 Neighboring gene STARR-positive B cell enhancer ABC_E9385 Neighboring gene predicted gene, 22748 Neighboring gene predicted gene, 36862 Neighboring gene predicted gene, 29864

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ornithine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ornithine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ornithine decarboxylase
    NP_001396552.1
    NP_001396553.1
    NP_001396556.1
    NP_001396557.1
    NP_001396558.1
    NP_001396560.1
    NP_001396561.1
    NP_001396562.1
    NP_001396563.1
    NP_001396564.1
    NP_001396565.1
    NP_001396566.1
    NP_001396567.1
    NP_001396568.1
    NP_001396569.1
    NP_001396570.1
    NP_001396571.1
    NP_001396572.1
    NP_001396573.1
    NP_001396574.1
    NP_038642.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409623.1NP_001396552.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    2. NM_001409624.1NP_001396553.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    3. NM_001409627.1NP_001396556.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    4. NM_001409628.1NP_001396557.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    5. NM_001409629.1NP_001396558.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    6. NM_001409631.1NP_001396560.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    7. NM_001409632.1NP_001396561.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    8. NM_001409633.1NP_001396562.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    9. NM_001409634.1NP_001396563.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    10. NM_001409635.1NP_001396564.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    11. NM_001409636.1NP_001396565.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
    12. NM_001409637.1NP_001396566.1  ornithine decarboxylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    13. NM_001409638.1NP_001396567.1  ornithine decarboxylase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    14. NM_001409639.1NP_001396568.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    15. NM_001409640.1NP_001396569.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    16. NM_001409641.1NP_001396570.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    17. NM_001409642.1NP_001396571.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    18. NM_001409643.1NP_001396572.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    19. NM_001409644.1NP_001396573.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    20. NM_001409645.1NP_001396574.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/TrEMBL
      Q3TM76
    21. NM_013614.3NP_038642.2  ornithine decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_038642.2

      Status: VALIDATED

      Source sequence(s)
      AC163651
      Consensus CDS
      CCDS25829.1
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
      Related
      ENSMUSP00000128661.2, ENSMUST00000171737.3
      Conserved Domains (1) summary
      cd00622
      Location:37408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17594906..17601503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001409630.1: Suppressed sequence

      Description
      NM_001409630.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.