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    MEP-1 MEP-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEP-1provided by FlyBase
    Official Full Name
    MEP-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035357
    Locus tag
    Dmel_CG1244
    See related
    AllianceGenome:FB:FBgn0035357
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.37; anon-WO0118547.584; CG1244; clone 1.37; Dmel\CG1244; dMEP-1; Mep-1; MEP1; Q0E8J0_DROME
    Summary
    Enables ATPase activator activity and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in nucleus and polytene chromosome. Part of NuRD complex. Is expressed in several structures, including adult brain cell body rind; adult head; germline cell; larval brain; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MEP-1 in Genome Data Viewer
    Location:
    62E8-62E8; 3-3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2631715..2641984)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2631715..2641984)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peroxidasin Neighboring gene long non-coding RNA:CR45982 Neighboring gene long non-coding RNA:CR45660 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster. Khalisova KY, et al. Dokl Biochem Biophys, 2021 May. PMID 34189645
    2. CRISPR/Cas9 Essential Gene Editing in Drosophila. Osadchiy IS, et al. Acta Naturae, 2023 Apr-Jun. PMID 37538801, Free PMC Article
    3. Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor. Guo X, et al. Nat Commun, 2024 Mar 26. PMID 38531872, Free PMC Article
    4. SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes. Godneeva B, et al. Elife, 2023 Nov 24. PMID 37999956, Free PMC Article
    5. Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific manner. Moshkin YM, et al. Mol Cell Biol, 2012 Feb. PMID 22124157, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster.
      Title: TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster.
    2. Genomewide expression analysis established that TTK69, MEP1, and Mi2 cooperate closely to control transcription.
      Title: Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MEP-1
    Names
    CG1244-PA
    CG1244-PB
    CG1244-PC
    CG1244-PD
    CG1244-PE
    CG1244-PF
    CG1244-PG
    MEP-1-PA
    MEP-1-PB
    MEP-1-PC
    MEP-1-PD
    MEP-1-PE
    MEP-1-PF
    MEP-1-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2631715..2641984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144403.2 → NP_001137875.1  MEP-1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    2. NM_167959.2 → NP_728762.1  MEP-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072808
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    3. NM_139476.3 → NP_647733.1  MEP-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072809
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    4. NM_167958.2 → NP_728761.1  MEP-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072810
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    5. NM_167960.2 → NP_728763.1  MEP-1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072811
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    6. NM_167962.2 → NP_728765.1  MEP-1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072812
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)

    7. NM_167961.2 → NP_728764.1  MEP-1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0, Q3KN57
      Related
      FBpp0072813
      Conserved Domains (2) summary
      sd00020
      Location:951 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05432
      Location:121 → 226
      BSP_II; Bone sialoprotein II (BSP-II)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8J0 Q0E8J0
    Q8T078 Q8T078

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