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    Sgsm1 small G protein signaling modulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 52850, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgsm1provided by MGI
    Official Full Name
    small G protein signaling modulator 1provided by MGI
    Primary source
    MGI:MGI:107320
    See related
    Ensembl:ENSMUSG00000042216 AllianceGenome:MGI:107320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NuIP; Rutbc2; D5Bwg1524e; E130107M15; 2410098H20Rik
    Summary
    Enables small GTPase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane. Is expressed in several structures, including brain and metanephros. Orthologous to human SGSM1 (small G protein signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 14.0), frontal lobe adult (RPKM 12.5) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sgsm1 in Genome Data Viewer
    Location:
    5 F; 5 55.45 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113391086..113458654, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113243220..113310788, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900026A02 gene Neighboring gene VISTA enhancer mm329 Neighboring gene predicted gene, 42161 Neighboring gene LHFPL tetraspan subfamily member 7 Neighboring gene STARR-seq mESC enhancer starr_14032 Neighboring gene microRNA 7229 Neighboring gene microRNA 7230

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    small G protein signaling modulator 1
    Names
    RUN and TBC1 domain containing 2
    RUN and TBC1 domain-containing protein 2
    nurr1-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162965.1NP_001156437.1  small G protein signaling modulator 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC130548, AC151577, AK044716, AK051018, AK053555
      UniProtKB/TrEMBL
      Q3TDT4
      Related
      ENSMUST00000145708.8
      Conserved Domains (3) summary
      smart00164
      Location:881961
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:254425
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:44188
      RUN; RUN domain
    2. NM_001254731.1NP_001241660.1  small G protein signaling modulator 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC130548, AK044716, DV644552
      Consensus CDS
      CCDS57374.1
      UniProtKB/TrEMBL
      D3YUT7, D3Z7V4
      Related
      ENSMUSP00000107944.2, ENSMUST00000112325.8
      Conserved Domains (2) summary
      smart00593
      Location:127187
      RUN; domain involved in Ras-like GTPase signaling
      cd15784
      Location:254425
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    3. NM_001309526.1NP_001296455.1  small G protein signaling modulator 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs, lacks a portion of the 5' and 3' coding regions, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC151577, AK051018
      Related
      ENSMUST00000147856.8
      Conserved Domains (2) summary
      smart00164
      Location:594674
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:14138
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    4. NM_001309528.1NP_001296457.1  small G protein signaling modulator 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AK051018, AK053555, AK167632, BP761545
      Consensus CDS
      CCDS84935.1
      UniProtKB/Swiss-Prot
      Q8BPQ7
      Related
      ENSMUSP00000084106.5, ENSMUST00000057209.12
      Conserved Domains (2) summary
      smart00164
      Location:594763
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:14138
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    5. NM_172718.3NP_766306.2  small G protein signaling modulator 1 isoform a

      See identical proteins and their annotated locations for NP_766306.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC130548, AK044716, AK053555, AK167632, BP761545
      Consensus CDS
      CCDS39218.1
      UniProtKB/Swiss-Prot
      Q3TJ12, Q8BPQ7
      UniProtKB/TrEMBL
      B2RQR5
      Related
      ENSMUSP00000046544.7, ENSMUST00000048112.13
      Conserved Domains (3) summary
      smart00164
      Location:8811050
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:254425
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:44188
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113391086..113458654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535122.4XP_006535185.1  small G protein signaling modulator 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TJ12, Q8BPQ7
      Conserved Domains (3) summary
      smart00164
      Location:9361105
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:254425
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:44186
      RUN; RUN domain