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    mgl Megalin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mglprovided by FlyBase
    Official Full Name
    Megalinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261260
    Locus tag
    Dmel_CG42611
    See related
    AllianceGenome:FB:FBgn0261260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.108; CG12139; CG12654; CG15316; CG34339; CG34352; CG42611; CT7830; Dm CG34352; Dmel\CG42611; LDLR; LRP-2; lrp2; megalin; Mgl; SOSIE
    Old locus tag
    CG12139; CG12654; Dmel_CG12139; Dmel_CG12654; Dmel_CG34339; Dmel_CG34352
    Summary
    Predicted to enable hormone binding activity. Involved in chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; and regulation of endocytosis. Located in apical plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; anterior-posterior subdivision of organism; epithelium; extraembryonic structure; and gut section. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mgl in Genome Data Viewer
    Location:
    8D9-8E4; 1-28 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9358496..9500129, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9252529..9394162, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene c12.2 Neighboring gene Zinc finger DHHC-type containing 8 Neighboring gene uncharacterized protein Neighboring gene BCL7-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncovering the footprint of positive selection on the X chromosome of Drosophila melanogaster. Orengo DJ, et al. Mol Biol Evol, 2010 Jan. PMID 19759233
    2. Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele. Hinaux H, et al. Dev Biol, 2018 Jun 15. PMID 29634916
    3. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Gleixner EM, et al. Cell Rep, 2014 Jul 10. PMID 24953654
    4. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
    5. The role of megalin (LRP-2/Gp330) during development. Fisher CE, et al. Dev Biol, 2006 Aug 15. PMID 16828734

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
      Title: Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of adult chitin-containing cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    megalin
    Names
    CG42611-PA
    CG42611-PC
    CG42611-PD
    CG42611-PE
    LDL receptor-related protein 2
    mgl-PA
    mgl-PC
    mgl-PD
    mgl-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9358496..9500129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298124.1 → NP_001285053.1  megalin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JTM7
      Conserved Domains (11) summary
      smart00192
      Location:1227 → 1259
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2671 → 2713
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:4163 → 4194
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:2867 → 2901
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2593 → 2622
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1188 → 1223
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4350 → 4390
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:3269 → 3292
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:1522 → 1553
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:447 → 488
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:2579 → 2711
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_001103454.3 → NP_001096924.2  megalin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096924.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JTM7
      Conserved Domains (11) summary
      smart00192
      Location:1227 → 1259
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2671 → 2713
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:4163 → 4194
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:2867 → 2901
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2593 → 2622
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1188 → 1223
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4350 → 4390
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:3269 → 3292
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:1522 → 1553
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:447 → 488
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:2579 → 2711
      NHL; NHL repeat unit of beta-propeller proteins

    3. NM_132335.3 → NP_572563.3  megalin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572563.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JTM7
      Conserved Domains (11) summary
      smart00192
      Location:1227 → 1259
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2671 → 2713
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:4163 → 4194
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:2867 → 2901
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2593 → 2622
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1188 → 1223
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4350 → 4390
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:3269 → 3292
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:1522 → 1553
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:447 → 488
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:2579 → 2711
      NHL; NHL repeat unit of beta-propeller proteins

    4. NM_001298125.1 → NP_001285054.1  megalin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JTM7
      Conserved Domains (11) summary
      smart00192
      Location:1227 → 1259
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2671 → 2713
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:4163 → 4194
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:2867 → 2901
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:2593 → 2622
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:1188 → 1223
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4350 → 4390
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:3269 → 3292
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:1522 → 1553
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:447 → 488
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl18310
      Location:2579 → 2711
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JTM7 A8JTM7
    Q95SN5 Q95SN5

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