Adcy2 adenylate cyclase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy2provided by RGD
Official Full Name: adenylate cyclase 2provided by RGD
Primary source: RGD:619965
See related: EnsemblRapid:ENSRNOG00000032150 AllianceGenome:RGD:619965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AC2
Summary: Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 209.9), Muscle (RPKM 172.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (36204054..36650645)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (34375639..34822252)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (37043071..37698390)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AC2 is poised to yield both stimulatory and inhibitory outcomes of receptor activation.
Title: Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.
AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser704.
Title: Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.
soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
Title: Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71322 (e-PCR)
- UniSTS:84774

MARC_4677-4678:996679594:1 (e-PCR)
- UniSTS:269415

RH132673 (e-PCR)
- UniSTS:215956

RH129915 (e-PCR)
- UniSTS:213203

D5S1607E (e-PCR)
- UniSTS:151028

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 2

Names: ATP pyrophosphate-lyase 2; adenylate cyclase 2 (brain); adenylate cyclase type II; adenylyl cyclase 2

NP_112269.2

EC 4.6.1.1

XP_038947960.1

EC 4.6.1.1

XP_038947965.1

EC 4.6.1.1

XP_038947966.1

EC 4.6.1.1

XP_038947972.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031007.3 → NP_112269.2 adenylate cyclase type 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P26769

UniProtKB/TrEMBL

A6JV23, F1LV12

Related

ENSRNOP00000038994.3, ENSRNOT00000047627.5

Conserved Domains (3) summary

pfam00211
Location:882 → 1081

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:37 → 264

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:499 → 603

DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

36204054..36650645

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092044.2 → XP_038947972.1 adenylate cyclase type 2 isoform X4

Conserved Domains (3) summary

pfam00211
Location:285 → 469

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:37 → 264

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:499 → 603

DUF1053; Domain of Unknown Function (DUF1053)
XM_039092038.2 → XP_038947966.1 adenylate cyclase type 2 isoform X3

Conserved Domains (3) summary

pfam00211
Location:285 → 469

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:37 → 264

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:499 → 603

DUF1053; Domain of Unknown Function (DUF1053)
XM_039092032.2 → XP_038947960.1 adenylate cyclase type 2 isoform X1

UniProtKB/Swiss-Prot

P26769

Conserved Domains (3) summary

pfam00211
Location:836 → 1035

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:37 → 264

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:499 → 603

DUF1053; Domain of Unknown Function (DUF1053)
XM_039092037.2 → XP_038947965.1 adenylate cyclase type 2 isoform X2

UniProtKB/Swiss-Prot

P26769

Related

ENSRNOP00000109970.1, ENSRNOT00000127647.1

Conserved Domains (3) summary

pfam00211
Location:816 → 1015

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:61 → 198

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:433 → 537

DUF1053; Domain of Unknown Function (DUF1053)