Dpep1 dipeptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpep1provided by RGD
Official Full Name: dipeptidase 1provided by RGD
Primary source: RGD:620324
See related: EnsemblRapid:ENSRNOG00000015880 AllianceGenome:RGD:620324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including beta-lactamase activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and metallodipeptidase activity. Predicted to be involved in several processes, including GPI anchor release; carboxylic acid metabolic process; and cellular response to nitric oxide. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and nucleoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 578.8), Kidney (RPKM 206.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68118270..68143781)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51209831..51237004)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55973447..55998830)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

carboxypeptidase A, dipeptidase and Na+/K+ ATPase levels in the rat intestine change when exposed to different doses of cadmium
Title: Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GPI anchor binding	ISO Inferred from Sequence Orthology more info
enables GPI anchor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-lactamase activity	ISO Inferred from Sequence Orthology more info
enables beta-lactamase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dipeptidase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables modified amino acid binding	ISO Inferred from Sequence Orthology more info
enables modified amino acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in antibiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in antibiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in homocysteine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in homocysteine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukotriene D4 catabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene D4 catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukotriene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dipeptidase 1

Names: beta-lactamase; dipeptidase 1 (renal); microsomal dipeptidase; renal dipeptidase

NP_446043.1

EC 3.4.13.19

EC 3.5.2.6

XP_006255845.1

EC 3.4.13.19

EC 3.5.2.6

XP_063134405.1

EC 3.4.13.19

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053591.2 → NP_446043.1 dipeptidase 1 precursor

See identical proteins and their annotated locations for NP_446043.1

Status: PROVISIONAL

Source sequence(s)

BC072476

UniProtKB/Swiss-Prot

P31430, Q6IN35

UniProtKB/TrEMBL

A6IZW1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)