Rgs7 regulator of G-protein signaling 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs7provided by RGD
Official Full Name: regulator of G-protein signaling 7provided by RGD
Primary source: RGD:3570
See related: EnsemblRapid:ENSRNOG00000021984 AllianceGenome:RGD:3570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein alpha-subunit binding activity and G-protein beta-subunit binding activity. Involved in several processes, including positive regulation of potassium ion transmembrane transport; response to amphetamine; and response to ethanol. Located in nuclear envelope. Part of protein-containing complex. Orthologous to human RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 259.6), Lung (RPKM 49.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (89511492..89941082, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (86979269..87408834, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (93095659..93534452, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Title: Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
the expression of RGS7 was increased following chronic stress exposure.
Title: Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Rat187 (e-PCR)
- UniSTS:226562

D13UIA7 (e-PCR)
- UniSTS:239624

RH131359 (e-PCR)
- UniSTS:214642

RH134962 (e-PCR)
- UniSTS:218239

AU046960 (e-PCR)
- UniSTS:110978

D13Ulb2 (e-PCR)
- UniSTS:518550

BF402644 (e-PCR)
- UniSTS:245944

D13Mco21 (e-PCR)
- UniSTS:240100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell tip	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite terminus	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019343.2 → NP_062216.1 regulator of G-protein signaling 7

See identical proteins and their annotated locations for NP_062216.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P49803, Q9R0R0

UniProtKB/TrEMBL

A0A8I6AKV4, A6JGB2

Related

ENSRNOP00000090982.2, ENSRNOT00000112294.2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

89511492..89941082 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272561.1 → XP_063128631.1 regulator of G-protein signaling 7 isoform X5

UniProtKB/TrEMBL

A0A8I6AKV4
XM_039091031.2 → XP_038946959.1 regulator of G-protein signaling 7 isoform X3

UniProtKB/TrEMBL

A0A8I6AAQ8, A0A8I6AKV4, A6JGB1

Related

ENSRNOP00000076773.2, ENSRNOT00000107041.2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_063272560.1 → XP_063128630.1 regulator of G-protein signaling 7 isoform X3

UniProtKB/TrEMBL

A0A8I6AAQ8, A0A8I6AKV4, A6JGB1
XM_063272559.1 → XP_063128629.1 regulator of G-protein signaling 7 isoform X3

UniProtKB/TrEMBL

A0A8I6AAQ8, A0A8I6AKV4, A6JGB1
XM_039091030.2 → XP_038946958.1 regulator of G-protein signaling 7 isoform X2

UniProtKB/TrEMBL

A0A8I5YBW3, A0A8I6AKV4

Related

ENSRNOP00000094085.2, ENSRNOT00000106278.2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_039091032.2 → XP_038946960.1 regulator of G-protein signaling 7 isoform X4

UniProtKB/TrEMBL

A0A8I6AKV4

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_039091028.2 → XP_038946956.1 regulator of G-protein signaling 7 isoform X1

UniProtKB/Swiss-Prot

P49803, Q9R0R0

UniProtKB/TrEMBL

A0A8I6AKV4, A6JGB2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_039091029.2 → XP_038946957.1 regulator of G-protein signaling 7 isoform X1

UniProtKB/Swiss-Prot

P49803, Q9R0R0

UniProtKB/TrEMBL

A0A8I6AKV4, A6JGB2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain