Slc15a1 solute carrier family 15 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc15a1provided by RGD
Official Full Name: solute carrier family 15 member 1provided by RGD
Primary source: RGD:621736
See related: EnsemblRapid:ENSRNOG00000011598 AllianceGenome:RGD:621736
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pept1
Summary: Enables channel inhibitor activity. Involved in metanephric proximal tubule development and negative regulation of amino acid transport. Located in apical plasma membrane. Orthologous to human SLC15A1 (solute carrier family 15 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 53.9), Testes (RPKM 6.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (104944461..104991316, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (98537641..98582544, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (106800081..106844668, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Role of cholinergic anti-inflammatory pathway in Ghrelin regulation of peptide transporter 1 expression in small intestinal epithelium of septic rats].
Title: [Role of cholinergic anti-inflammatory pathway in Ghrelin regulation of peptide transporter 1 expression in small intestinal epithelium of septic rats].
Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule.
Title: Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule.
Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats.
Title: Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats.
Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation.
Title: Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation.
Inhibition of upper small intestinal peptide transporter 1 (PepT1), the primary oligopeptide transporter in the small intestine, reverses the preabsorptive ability of upper small intestinal casein infusion to increase glucose tolerance and suppress glucose production.
Title: Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing.
PepT1 expression was confirmed by immunofluorescence on monolayers and brush border of rat jejunal tissue.
Title: Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models.
The expressions of PepT1 mRNA and protein were higher in ghrelin-treated group rats.
Title: Ghrelin upregulates PepT1 activity in the small intestine epithelium of rats with sepsis.
Slc15a1 is involved in the transport of synthetic F5-peptide into seminiferous epithelium.
Title: Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes.
Data suggest that PepT1 transports the vasoactive dipeptide Trp-His (but not His-Trp which undergoes rapid proteolysis) across the rat intestinal membrane; this mechanism may account for anti-atherosclerotic action of Trp-His as a dietary supplement.
Title: Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses.
Nod2-Rip2-NFkappaB signaling involved in the small intestinal inflammatory injury caused by muramyl dipeptide which is transported through PepT1.
Title: Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats.

Submit: New GeneRIF Correction See all GeneRIFs (34)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables peptide:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oligopeptide transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligopeptide transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tripeptide transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 15 member 1

Names: intestinal H(+)/peptide cotransporter; peptide transporter 1; pineal gland-specific PEPT1; proton-coupled dipeptide cotransporter; solute carrier family 15 (oligopeptide transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079838.1 → NP_001073307.1 solute carrier family 15 member 1 isoform pgPepT1

See identical proteins and their annotated locations for NP_001073307.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) lacks alternate exons in the 5' UTR and 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (pgPepT1) has a distinct N-terminus and is shorter than isoform PepT1.

Source sequence(s)

AY860424

UniProtKB/Swiss-Prot

P51574

Conserved Domains (1) summary

cl21472
Location:11 → 74

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_057121.2 → NP_476462.2 solute carrier family 15 member 1 isoform PepT1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer isoform (PepT1).

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P51574, Q5EML1

UniProtKB/TrEMBL

A6HUK3, F1LMZ1

Related

ENSRNOP00000015890.7, ENSRNOT00000015890.8

Conserved Domains (1) summary

TIGR00926
Location:28 → 672

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)