Ndrg4 NDRG family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndrg4provided by RGD
Official Full Name: NDRG family member 4provided by RGD
Primary source: RGD:621593
See related: EnsemblRapid:ENSRNOG00000012482 AllianceGenome:RGD:621593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bdm1; Ndr4; smap8
Summary: Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of neuron projection development. Located in endoplasmic reticulum membrane. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2291.3) and Heart (RPKM 754.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (9357470..9393465, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (9351408..9387398, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (9766439..9802396, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of MiR-218-5p Protects Against Oxygen-Glucose Deprivation/Reperfusion-Induced Injuries of PC12 Cells via Upregulating N-myc Downstream Regulated Gene 4 (NDRG4).
Title: Downregulation of MiR-218-5p Protects Against Oxygen-Glucose Deprivation/Reperfusion-Induced Injuries of PC12 Cells via Upregulating N-myc Downstream Regulated Gene 4 (NDRG4).
Authors found that NDRG4 expression was upregulated during the early stage and decreased 24 h after ischemia/reperfusion (I/R) injury, and NDRG4 overexpression decreased the infarct size and mitigated the neurological deficits induced by I/R injury by inhibiting apoptosis.
Title: NDRG4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis.
expression increased in injured neonatal ventricular myocytes
Title: N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway.
NDRG4A2 is expressed in pancreatic duct cells under GLP-1 control and may be related to a reduction in proliferation and the onset of the pancreas cell differentiation.
Title: Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas.
May play a role in supporting activation of extracellular signal-regulated MAP kinase (ERK) and its target proteins needed for neuronal differentiation and in reducing the activation of Elk-1 implicated in cell growth.
Title: Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation.
This is the first evidence of irSMAP8 in a population of VP/OT-containing hypothalamic neurons in the rat, and the peptide is biologically active in hypothalamic neurons, as evidenced by mobilization of extracellular Ca2+.
Title: Smooth muscle-associated protein 8: distribution and biological activity in the rat brain.
Molecular characterization of NDRG4 protein isoforms that are differentially regulated during rat brain development.
Title: Molecular characterization of NDRG4/Bdm1 protein isoforms that are differentially regulated during rat brain development.
smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury [SMAP8]
Title: A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell migration involved in heart development	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein NDRG4

Names: N-myc downstream regulated 4; N-myc downstream regulated gene 4; brain development-related molecule 1; development-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271091.1 → NP_001258020.1 protein NDRG4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

CB585874, CB713901, FM054107, JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6G5X2, D3ZUT8

Related

ENSRNOP00000044520.2, ENSRNOT00000051414.6

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001271092.1 → NP_001258021.1 protein NDRG4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB585874, FM054107, JAXUCZ010000019

UniProtKB/TrEMBL

A6JXZ4, D3Z831

Related

ENSRNOP00000017494.5, ENSRNOT00000017494.8

Conserved Domains (1) summary

pfam03096
Location:60 → 342

Ndr; Ndr family
NM_001271093.1 → NP_001258022.1 protein NDRG4 isoform 3

See identical proteins and their annotated locations for NP_001258022.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

CB585874, CB713901, FM054107, JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6G5X2

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
NM_001271094.1 → NP_001258023.1 protein NDRG4 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

CB585874, FM054107, JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6G5X2

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
NM_001271095.1 → NP_001258024.1 protein NDRG4 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

CB585874, FM054107, JAXUCZ010000019

UniProtKB/Swiss-Prot

Q6XQ62, Q6XQ63, Q6XQ64, Q6XQ65, Q78ZK9, Q7TST8, Q9Z2L9

Related

ENSRNOP00000084746.2, ENSRNOT00000116737.2

Conserved Domains (1) summary

pfam03096
Location:8 → 290

Ndr; Ndr family
NM_031967.2 → NP_114173.2 protein NDRG4 isoform 5

See identical proteins and their annotated locations for NP_114173.2

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

CB585874, CB713901, FM054107, JAXUCZ010000019

UniProtKB/Swiss-Prot

Q6XQ62, Q6XQ63, Q6XQ64, Q6XQ65, Q78ZK9, Q7TST8, Q9Z2L9

UniProtKB/TrEMBL

A6JXZ5

Related

ENSRNOP00000017413.6, ENSRNOT00000017413.8

Conserved Domains (1) summary

pfam03096
Location:8 → 290

Ndr; Ndr family