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    Mcpt10 mast cell protease 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcpt10provided by RGD
    Official Full Name
    mast cell protease 10provided by RGD
    Primary source
    RGD:3063
    See related
    EnsemblRapid:ENSRNOG00000068082 AllianceGenome:RGD:3063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLP-2; GLP II; rMCP-X; rMCP-10
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 78.3), Spleen (RPKM 71.4) and 3 other tissues See more
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    Genomic context

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    See Mcpt10 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33885728..33888787, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29915483..29918540, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34644471..34647497, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene mast cell protease 1 Neighboring gene mast cell protease 1-like 1 Neighboring gene cathepsin G Neighboring gene granzyme N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum. Amerik AYu, et al. FEBS Lett, 1993 Jun 14. PMID 8508925
    2. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lützelschwab C, et al. J Exp Med, 1997 Jan 6. PMID 8996238, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    granzyme-like protein 2
    Names
    granzyme-like protein II
    mast cell protease X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017146.3 → NP_058842.3  granzyme-like protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q06606
      UniProtKB/TrEMBL
      A0A8I5ZX66, A0A8I6A223
      Related
      ENSRNOP00000086840.1, ENSRNOT00000107633.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33885728..33888787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093844.2 → XP_038949772.1  granzyme-like protein 2 isoform X1

      Conserved Domains (1) summary
      smart00020
      Location:20 → 196
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06606.2 GenPept UniProtKB/Swiss-Prot:Q06606

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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