Ak4 adenylate kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ak4provided by RGD
Official Full Name: adenylate kinase 4provided by RGD
Primary source: RGD:2078
See related: AllianceGenome:RGD:2078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AK 4; Ak3l1; Ak3l2
Summary: Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in liver development and response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Biomarker of acute kidney tubular necrosis. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1264.8), Liver (RPKM 558.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (121154565..121214403)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (116039222..116099064)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (120250318..120309153)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
Title: MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (deoxy)adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables dCMP kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside triphosphate adenylate kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables nucleoside triphosphate adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate adenylate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in ribonucleoside diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ribonucleoside diphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate kinase 4, mitochondrial

Names: ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase 3-like 2; adenylate kinase isoenzyme 4, mitochondrial

NP_058831.1

EC 2.7.4.4

EC 2.7.4.6

XP_017448685.1

EC 2.7.4.4

EC 2.7.4.6

XP_038965281.1

EC 2.7.4.4

EC 2.7.4.6

XP_063143316.1

EC 2.7.4.4

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429545.1 → NP_001416474.1 adenylate kinase 4, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9WUS0

UniProtKB/TrEMBL

A0A8L2QYP3
NM_001429546.1 → NP_001416475.1 adenylate kinase 4, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9WUS0

UniProtKB/TrEMBL

A0A8L2QYP3
NM_001429547.1 → NP_001416476.1 adenylate kinase 4, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2QYP3, A6JRN4
NM_001429548.1 → NP_001416477.1 adenylate kinase 4, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JRN6
NM_017135.4 → NP_058831.1 adenylate kinase 4, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_058831.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9WUS0

UniProtKB/TrEMBL

A0A8L2QYP3

Conserved Domains (1) summary

TIGR01351
Location:7 → 211

adk; adenylate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

121154565..121214403

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593196.3 → XP_017448685.1 adenylate kinase 4, mitochondrial isoform X1

Conserved Domains (1) summary

TIGR01351
Location:7 → 211

adk; adenylate kinase
XM_063287246.1 → XP_063143316.1 adenylate kinase 4, mitochondrial isoform X1
XM_039109353.2 → XP_038965281.1 adenylate kinase 4, mitochondrial isoform X2

Conserved Domains (1) summary

pfam00406
Location:1 → 116

ADK; Adenylate kinase