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    Iqgap2 IQ motif containing GTPase activating protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqgap2provided by RGD
    Official Full Name
    IQ motif containing GTPase activating protein 2provided by RGD
    Primary source
    RGD:2321734
    See related
    EnsemblRapid:ENSRNOG00000025406 AllianceGenome:RGD:2321734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including filopodium; lamellipodium; and microvillus. Predicted to be active in cell cortex. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 965.7), Liver (RPKM 600.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iqgap2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (28629558..28904649, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26894836..27170270, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (26161628..26439067, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2 like 2 Neighboring gene uncharacterized LOC134485820 Neighboring gene coagulation factor II (thrombin) receptor Neighboring gene uncharacterized LOC120100669 Neighboring gene uncharacterized LOC134485821 Neighboring gene coagulation factor II (thrombin) receptor-like 2 Neighboring gene uncharacterized LOC120100671 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC120100552

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Schmidt VA, et al. Blood, 2003 Apr 15. PMID 12515716
    2. IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. Dixon MJ, et al. J Biol Chem, 2012 Jun 29. PMID 22493426, Free PMC Article
    3. IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain. Atcheson E, et al. Biosci Rep, 2011 Oct. PMID 21299499, Free PMC Article
    4. IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nojima H, et al. Nat Cell Biol, 2008 Aug. PMID 18604197
    5. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427125.1 → NP_001414054.1  ras GTPase-activating-like protein IQGAP2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AM38, F1LW74
      Related
      ENSRNOP00000089989.1, ENSRNOT00000107205.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      28629558..28904649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281081.1 → XP_063137151.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      UniProtKB/TrEMBL
      F1LW74

    2. XM_008760685.4 → XP_008758907.1  ras GTPase-activating-like protein IQGAP2 isoform X3

      Conserved Domains (5) summary
      smart00015
      Location:246 → 263
      IQ; Calmodulin-binding motif
      smart00456
      Location:148 → 180
      WW; Domain with 2 conserved Trp (W) residues
      cd05131
      Location:469 → 827
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:458 → 810
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:920 → 1051
      RasGAP_C; RasGAP C-terminus

    3. XM_039103457.2 → XP_038959385.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      Conserved Domains (4) summary
      smart00015
      Location:273 → 290
      IQ; Calmodulin-binding motif
      smart00456
      Location:175 → 207
      WW; Domain with 2 conserved Trp (W) residues
      cd05131
      Location:496 → 854
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:364 → 1155
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

    4. XM_039103458.2 → XP_038959386.1  ras GTPase-activating-like protein IQGAP2 isoform X4

      Conserved Domains (4) summary
      smart00015
      Location:240 → 257
      IQ; Calmodulin-binding motif
      smart00456
      Location:142 → 174
      WW; Domain with 2 conserved Trp (W) residues
      cd05131
      Location:463 → 821
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:331 → 1122
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version

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