Trim37 tripartite motif-containing 37 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim37provided by RGD
Official Full Name: tripartite motif-containing 37provided by RGD
Primary source: RGD:1308349
See related: EnsemblRapid:ENSRNOG00000006248 AllianceGenome:RGD:1308349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including histone H2AK119 ubiquitin ligase activity; protein homodimerization activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including aggresome assembly; protein ubiquitination; and regulation of DNA-templated transcription. Predicted to be located in cytosol and peroxisome. Predicted to be part of ESC/E(Z) complex. Predicted to be active in aggresome and peroxisomal membrane. Human ortholog(s) of this gene implicated in mulibrey nanism. Orthologous to human TRIM37 (tripartite motif containing 37). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 265.6), Brain (RPKM 168.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (72440672..72572831)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (71943384..72075563)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (74436165..74568636)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AW537030 (e-PCR)
- UniSTS:179241

ksks326 (e-PCR)
- UniSTS:514371

D10Chm3 (e-PCR)
- UniSTS:518329

RH140321 (e-PCR)
- UniSTS:222398

D10Chm68 (e-PCR)
- UniSTS:518081

RH129417 (e-PCR)
- UniSTS:212724

RH129165 (e-PCR)
- UniSTS:212473

D10Chm5 (e-PCR)
- UniSTS:518395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AK119 ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aggresome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
is_active_in aggresome	IBA Inferred from Biological aspect of Ancestor more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM37

Names: tripartite motif protein 37

NP_001101758.1

EC 2.3.2.27

XP_006247161.1

EC 2.3.2.27

XP_006247163.1

EC 2.3.2.27

XP_006247164.1

EC 2.3.2.27

XP_006247166.1

EC 2.3.2.27

XP_008766296.1

EC 2.3.2.27

XP_038942303.1

EC 2.3.2.27

XP_038942304.1

EC 2.3.2.27

XP_038942305.1

EC 2.3.2.27

XP_038942306.1

EC 2.3.2.27

XP_063125467.1

EC 2.3.2.27

XP_063125468.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108288.2 → NP_001101758.1 E3 ubiquitin-protein ligase TRIM37

See identical proteins and their annotated locations for NP_001101758.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2KA84, A0A8I5ZJG0, A6HHT2

Related

ENSRNOP00000075301.2, ENSRNOT00000090921.3

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

72440672..72572831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247104.5 → XP_006247166.1 E3 ubiquitin-protein ligase TRIM37 isoform X5

See identical proteins and their annotated locations for XP_006247166.1

UniProtKB/TrEMBL

A0A0G2JVT0, B5DF77, D3ZL82

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_039086375.2 → XP_038942303.1 E3 ubiquitin-protein ligase TRIM37 isoform X4

UniProtKB/TrEMBL

A0A8I5ZJG0

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

cd19779
Location:93 → 132

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_006247102.5 → XP_006247164.1 E3 ubiquitin-protein ligase TRIM37 isoform X3

UniProtKB/TrEMBL

A0A8I5ZJG0

Related

ENSRNOP00000008299.8, ENSRNOT00000008298.8

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_006247099.5 → XP_006247161.1 E3 ubiquitin-protein ligase TRIM37 isoform X1

UniProtKB/TrEMBL

A0A8I5ZJG0

Related

ENSRNOP00000109052.1, ENSRNOT00000163542.1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_006247101.5 → XP_006247163.1 E3 ubiquitin-protein ligase TRIM37 isoform X2

UniProtKB/TrEMBL

A0A8I5ZJG0

Related

ENSRNOP00000100521.1, ENSRNOT00000149423.1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_063269397.1 → XP_063125467.1 E3 ubiquitin-protein ligase TRIM37 isoform X7

UniProtKB/TrEMBL

A0A8I5ZJG0
XM_008768074.4 → XP_008766296.1 E3 ubiquitin-protein ligase TRIM37 isoform X6

UniProtKB/TrEMBL

A0A8I5ZJG0

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger
XM_063269398.1 → XP_063125468.1 E3 ubiquitin-protein ligase TRIM37 isoform X9

UniProtKB/TrEMBL

A0A8I5ZJG0
XM_039086376.2 → XP_038942304.1 E3 ubiquitin-protein ligase TRIM37 isoform X8

UniProtKB/TrEMBL

A0A8I5ZJG0

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

cd19779
Location:93 → 132

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_039086377.2 → XP_038942305.1 E3 ubiquitin-protein ligase TRIM37 isoform X10

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

cd19779
Location:93 → 132

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_039086378.1 → XP_038942306.1 E3 ubiquitin-protein ligase TRIM37 isoform X11

UniProtKB/TrEMBL

A0A8I5ZJG0

Conserved Domains (3) summary

smart00502
Location:117 → 239

BBC; B-Box C-terminal domain

cd03773
Location:258 → 391

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd19779
Location:78 → 117

Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins