Cmas cytidine monophosphate N-acetylneuraminic acid synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmasprovided by RGD
Official Full Name: cytidine monophosphate N-acetylneuraminic acid synthetaseprovided by RGD
Primary source: RGD:1310911
See related: EnsemblRapid:ENSRNOG00000013816 AllianceGenome:RGD:1310911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N-acylneuraminate cytidylyltransferase activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process and glycosylation. Predicted to be located in nucleus. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 288.2), Liver (RPKM 281.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (177449801..177468117)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (175718808..175737128)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176994129..177012445)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131050 (e-PCR)
- UniSTS:214333

CMAS (e-PCR)
- UniSTS:503973

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acylneuraminate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylneuraminate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-acylneuraminate cytidylyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CMP-N-acetylneuraminate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in N-acetylneuraminate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycosylation	IEA Inferred from Electronic Annotation more info
involved_in glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acylneuraminate cytidylyltransferase

Names: CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; cytidine 5'-monophosphate N-acetylneuraminic acid synthetase; cytidine monophospho-N-acetylneuraminic acid synthetase

NP_001009419.1

EC 2.7.7.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009419.1 → NP_001009419.1 N-acylneuraminate cytidylyltransferase

See identical proteins and their annotated locations for NP_001009419.1

Status: PROVISIONAL

Source sequence(s)

BC087599

UniProtKB/Swiss-Prot

P69060

UniProtKB/TrEMBL

F7F0E0, Q5M963

Related

ENSRNOP00000018734.3, ENSRNOT00000018734.7

Conserved Domains (2) summary

cd02513
Location:42 → 257

CMP-NeuAc_Synthase; CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety

cd01630
Location:273 → 417

HAD_KDO-like; haloacid dehalogenase-like (HAD) hydrolase, similar to Escherichia coli 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) phosphatase KdsC, and rainbow trout N-acylneuraminate cytidylyltransferase