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    Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Enpp4provided by RGD
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 4provided by RGD
    Primary source
    RGD:1308689
    See related
    EnsemblRapid:ENSRNOG00000010174 AllianceGenome:RGD:1308689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable bis(5'-adenosyl)-triphosphatase activity. Predicted to be involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Predicted to be located in plasma membrane. Orthologous to human ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 76.5), Spleen (RPKM 46.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enpp4 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (24386351..24396248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (16888923..16898860)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (19446807..19457946)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351895 Neighboring gene uncharacterized LOC134480346 Neighboring gene uncharacterized LOC102555783 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Neighboring gene regulator of calcineurin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Albright RA, et al. Blood, 2012 Nov 22. PMID 22995898, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine ribonucleoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bis(5'-adenosyl)-triphosphatase ENPP4
    Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 4
    NP_001100362.1
    XP_006244660.1
    XP_006244662.1
    XP_006244663.1
    XP_006244664.1
    XP_008765074.1
    XP_017451819.1
    XP_063122931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106892.3 → NP_001100362.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001100362.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18
      Conserved Domains (1) summary
      cd16018
      Location:26 → 379
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. NM_001432291.1 → NP_001419220.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    3. NM_001432292.1 → NP_001419221.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    4. NM_001432295.1 → NP_001419224.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    5. NM_001432296.1 → NP_001419225.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    6. NM_001432297.1 → NP_001419226.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    7. NM_001432298.1 → NP_001419227.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ18

    8. NM_001432300.1 → NP_001419229.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    9. NM_001432301.1 → NP_001419230.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    10. NM_001432302.1 → NP_001419231.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    11. NM_001432303.1 → NP_001419232.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    12. NM_001432304.1 → NP_001419233.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    13. NM_001432305.1 → NP_001419234.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    14. NM_001432306.1 → NP_001419235.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    15. NM_001432307.1 → NP_001419236.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    16. NM_001432308.1 → NP_001419237.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      24386351..24396248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244600.5 → XP_006244662.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X2

      UniProtKB/TrEMBL
      F1LTZ5
      Related
      ENSRNOP00000099066.1, ENSRNOT00000172326.1
      Conserved Domains (2) summary
      pfam01663
      Location:145 → 456
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:143 → 496
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. XM_006244601.5 → XP_006244663.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X3

      Conserved Domains (2) summary
      pfam01663
      Location:189 → 373
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:190 → 413
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. XM_006244598.5 → XP_006244660.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1

      UniProtKB/TrEMBL
      D4A2W1
      Related
      ENSRNOP00000110540.1, ENSRNOT00000134157.1
      Conserved Domains (2) summary
      pfam01663
      Location:179 → 490
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:177 → 530
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    4. XM_017596330.3 → XP_017451819.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X5

      Conserved Domains (1) summary
      cd16018
      Location:26 → 379
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    5. XM_006244602.5 → XP_006244664.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X4

      Related
      ENSRNOP00000050116.6, ENSRNOT00000045937.6
      Conserved Domains (2) summary
      pfam01663
      Location:45 → 356
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:43 → 396
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    6. XM_008766852.4 → XP_008765074.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X5

      Related
      ENSRNOP00000059215.4, ENSRNOT00000065048.6
      Conserved Domains (1) summary
      cd16018
      Location:26 → 379
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    7. XM_063266861.1 → XP_063122931.1  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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