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    Cep57l1 centrosomal protein 57-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep57l1provided by RGD
    Official Full Name
    centrosomal protein 57-like 1provided by RGD
    Primary source
    RGD:1311358
    See related
    EnsemblRapid:ENSRNOG00000000303 AllianceGenome:RGD:1311358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    cep57R
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Orthologous to human CEP57L1 (centrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 77.2), Adrenal (RPKM 47.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep57l1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46820350..46876911, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45238039..45294575, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46610144..46666780, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483931 Neighboring gene coiled-coil domain containing 162 Neighboring gene uncharacterized LOC120098881 Neighboring gene sestrin 1 Neighboring gene armadillo repeat containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein CEP57L1
    Names
    centrosomal protein 57kDa-like protein 1
    centrosomal protein of 57 kDa-related protein
    cep57-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017448.2 → NP_001017448.2  centrosomal protein CEP57L1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0H2UH91, A6K701
      Related
      ENSRNOP00000089494.1, ENSRNOT00000111438.2
      Conserved Domains (2) summary
      pfam06657
      Location:301 → 372
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:66 → 243
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      46820350..46876911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098619.2 → XP_038954547.1  centrosomal protein CEP57L1 isoform X6

      Conserved Domains (1) summary
      pfam14073
      Location:91 → 268
      Cep57_CLD; Centrosome localization domain of Cep57

    2. XM_063279078.1 → XP_063135148.1  centrosomal protein CEP57L1 isoform X7

    3. XM_063279076.1 → XP_063135146.1  centrosomal protein CEP57L1 isoform X4

      UniProtKB/TrEMBL
      A6K701

    4. XM_006256565.4 → XP_006256627.1  centrosomal protein CEP57L1 isoform X3

      See identical proteins and their annotated locations for XP_006256627.1

      UniProtKB/Swiss-Prot
      Q6AXZ4
      UniProtKB/TrEMBL
      A6K701
      Conserved Domains (2) summary
      pfam06657
      Location:284 → 357
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    5. XM_006256563.5 → XP_006256625.1  centrosomal protein CEP57L1 isoform X2

      UniProtKB/TrEMBL
      A6K701
      Conserved Domains (4) summary
      pfam06657
      Location:310 → 381
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:91 → 252
      Cep57_CLD; Centrosome localization domain of Cep57
      cd16269
      Location:178 → 189
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:90 → 206
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. XM_006256562.5 → XP_006256624.1  centrosomal protein CEP57L1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLF7, A6K701
      Related
      ENSRNOP00000090876.2, ENSRNOT00000104623.2
      Conserved Domains (2) summary
      pfam06657
      Location:326 → 397
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:91 → 268
      Cep57_CLD; Centrosome localization domain of Cep57

    7. XM_006256567.5 → XP_006256629.1  centrosomal protein CEP57L1 isoform X3

      See identical proteins and their annotated locations for XP_006256629.1

      UniProtKB/Swiss-Prot
      Q6AXZ4
      UniProtKB/TrEMBL
      A6K701
      Conserved Domains (2) summary
      pfam06657
      Location:284 → 357
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    8. XM_039098618.2 → XP_038954546.1  centrosomal protein CEP57L1 isoform X3

      UniProtKB/Swiss-Prot
      Q6AXZ4
      UniProtKB/TrEMBL
      A6K701
      Conserved Domains (2) summary
      pfam06657
      Location:284 → 357
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    9. XM_063279077.1 → XP_063135147.1  centrosomal protein CEP57L1 isoform X5

      UniProtKB/TrEMBL
      A6K701
      Related
      ENSRNOP00000084661.1, ENSRNOT00000094398.2

    10. XM_006256566.5 → XP_006256628.1  centrosomal protein CEP57L1 isoform X3

      See identical proteins and their annotated locations for XP_006256628.1

      UniProtKB/Swiss-Prot
      Q6AXZ4
      UniProtKB/TrEMBL
      A6K701
      Related
      ENSRNOP00000108566.1, ENSRNOT00000166206.1
      Conserved Domains (2) summary
      pfam06657
      Location:284 → 357
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50 → 227
      Cep57_CLD; Centrosome localization domain of Cep57

    11. XM_039098621.2 → XP_038954549.1  centrosomal protein CEP57L1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZL1
      Conserved Domains (2) summary
      pfam06657
      Location:150 → 223
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:1 → 93
      Cep57_CLD; Centrosome localization domain of Cep57
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXZ4.1 GenPept UniProtKB/Swiss-Prot:Q6AXZ4

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