Parp16 poly (ADP-ribose) polymerase family, member 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp16provided by RGD
Official Full Name: poly (ADP-ribose) polymerase family, member 16provided by RGD
Primary source: RGD:1306243
See related: AllianceGenome:RGD:1306243
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ARTD15; LRRGT00109; RGD1306243
Summary: Predicted to enable NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 78.9), Adrenal (RPKM 72.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (74626399..74644610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (65731152..65749438)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (70712393..70731212)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging.
Title: Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in IRE1-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	IEA Inferred from Electronic Annotation more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum tubular network	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP16

Names: ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; mono [ADP-ribose] polymerase PARP16; poly [ADP-ribose] polymerase 16

NP_001014115.1

EC 2.4.2.30

XP_038937432.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014093.1 → NP_001014115.1 protein mono-ADP-ribosyltransferase PARP16

See identical proteins and their annotated locations for NP_001014115.1

Status: PROVISIONAL

Source sequence(s)

BC085908

UniProtKB/Swiss-Prot

Q5U2Q4

UniProtKB/TrEMBL

A6J5E5

Conserved Domains (2) summary

pfam00644
Location:102 → 273

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam18084
Location:15 → 90

ARTD15_N; ARTD15 N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

74626399..74644610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081504.2 → XP_038937432.1 protein mono-ADP-ribosyltransferase PARP16 isoform X1

UniProtKB/Swiss-Prot

Q5U2Q4

UniProtKB/TrEMBL

A6J5E5

Conserved Domains (2) summary

pfam00644
Location:102 → 273

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam18084
Location:15 → 90

ARTD15_N; ARTD15 N-terminal domain