Nectin2 nectin cell adhesion molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nectin2provided by RGD
Official Full Name: nectin cell adhesion molecule 2provided by RGD
Primary source: RGD:1309505
See related: EnsemblRapid:ENSRNOG00000018730 AllianceGenome:RGD:1309505
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pvrl2
Summary: Predicted to enable cell adhesion molecule binding activity and protein homodimerization activity. Predicted to be involved in several processes, including coreceptor-mediated virion attachment to host cell; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of immune response. Predicted to act upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and zonula adherens. Predicted to be active in apical junction complex and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 104.0), Liver (RPKM 99.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88500086..88535474, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79372123..79407379, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80631449..80666617, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cells transfected with the dynamin 3 construct had less uniformly distributed nectin 2 at intercellular contacts when compared to control cells.
Title: The role of dynamin 3 in the testis.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Got83 (e-PCR)
- UniSTS:115982

D1S3690 (e-PCR)
- UniSTS:474268

BE102426 (e-PCR)
- UniSTS:244185

RH130455 (e-PCR)
- UniSTS:213739

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular anatomical entity morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
involved_in coreceptor-mediated virion attachment to host cell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of mitochondrion localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid nucleus differentiation	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in zonula adherens	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nectin-2

Names: poliovirus receptor related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012064.1 → NP_001012064.1 nectin-2 precursor

See identical proteins and their annotated locations for NP_001012064.1

Status: PROVISIONAL

Source sequence(s)

BC090075

UniProtKB/TrEMBL

A0A8I6A2S9, Q5FVC5

Related

ENSRNOP00000025388.5, ENSRNOT00000025388.8

Conserved Domains (3) summary

cd05718
Location:48 → 150

Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins

smart00410
Location:40 → 149

IG_like; Immunoglobulin like

cl11960
Location:153 → 248

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88500086..88535474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228421.4 → XP_006228483.1 nectin-2 isoform X1

See identical proteins and their annotated locations for XP_006228483.1

UniProtKB/TrEMBL

A0A0G2KA71, A6J8U5

Conserved Domains (3) summary

cd05718
Location:48 → 150

Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins

smart00410
Location:40 → 149

IG_like; Immunoglobulin like

cl11960
Location:153 → 248

Ig; Immunoglobulin domain