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    Mia2 MIA SH3 domain ER export factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912115, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mia2provided by RGD
    Official Full Name
    MIA SH3 domain ER export factor 2provided by RGD
    Primary source
    RGD:6488546
    See related
    EnsemblRapid:ENSRNOG00000005101 AllianceGenome:RGD:6488546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgea6; Ctage5
    Summary
    Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; and protein transport. Predicted to act upstream of or within cholesterol homeostasis and triglyceride homeostasis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Orthologous to several human genes including MIA2 (MIA SH3 domain ER export factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 408.4), Kidney (RPKM 298.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mia2 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (82522398..82620136)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (76787508..76885246)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (80188721..80286918)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 6B Neighboring gene pinin, desmosome associated protein Neighboring gene small nucleolar RNA, H/ACA box 26 like 1 Neighboring gene F-box protein 33 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites. Pitman JL, et al. J Lipid Res, 2011 Oct. PMID 21807889, Free PMC Article
    2. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. Tanabe T, et al. Mol Biol Cell, 2016 Jul 1. PMID 27170179, Free PMC Article
    3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. Santos AJ, et al. J Cell Biol, 2016 May 9. PMID 27138255, Free PMC Article
    4. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Saito K, et al. Mol Biol Cell, 2011 Jul 1. PMID 21525241, Free PMC Article
    5. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. Saito K, et al. J Cell Biol, 2014 Sep 15. PMID 25202031, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulation of guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma inhibitory activity protein 2
    Names
    CTAGE family member 5, ER export factor
    CTAGE family, member 5
    cutaneous T-cell lymphoma-associated antigen 5 homolog
    melanoma inhibitory activity 2
    meningioma expressed antigen 6 (coiled-coil proline-rich)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371341.1 → NP_001358270.1  melanoma inhibitory activity protein 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSK4
      Related
      ENSRNOP00000081248.1, ENSRNOT00000103916.2
      Conserved Domains (3) summary
      PHA03247
      Location:1190 → 1400
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:671 → 1105
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl17036
      Location:31 → 103
      SH3; Src Homology 3 domain superfamily

    2. NM_001371347.1 → NP_001358276.1  melanoma inhibitory activity protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several coding exons and reflects the use of an alternate internal promoter, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct N-terminus, compared to isoform 1
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZVL1
      Conserved Domains (2) summary
      PHA03247
      Location:548 → 758
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:62 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      82522398..82620136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764679.4 → XP_008762901.2  melanoma inhibitory activity protein 2 isoform X4

    2. XM_017594453.3 → XP_017449942.1  melanoma inhibitory activity protein 2 isoform X5

    3. XM_039111595.2 → XP_038967523.1  melanoma inhibitory activity protein 2 isoform X10

      Conserved Domains (3) summary
      COG1196
      Location:771 → 1048
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:642 → 867
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cl17036
      Location:31 → 103
      SH3; Src Homology 3 domain superfamily

    4. XM_017594450.3 → XP_017449939.1  melanoma inhibitory activity protein 2 isoform X1

      UniProtKB/TrEMBL
      D3ZVK5
      Related
      ENSRNOP00000056080.5, ENSRNOT00000059318.6

    5. XM_063261379.1 → XP_063117449.1  melanoma inhibitory activity protein 2 isoform X6

    6. XM_008764680.4 → XP_008762902.2  melanoma inhibitory activity protein 2 isoform X7

      Related
      ENSRNOP00000070325.3, ENSRNOT00000089010.3

    7. XM_017594451.3 → XP_017449940.1  melanoma inhibitory activity protein 2 isoform X2

    8. XM_063261380.1 → XP_063117450.1  melanoma inhibitory activity protein 2 isoform X8

    9. XM_017594452.3 → XP_017449941.1  melanoma inhibitory activity protein 2 isoform X3

      Related
      ENSRNOP00000056095.5, ENSRNOT00000059335.5

    10. XM_039111594.2 → XP_038967522.1  melanoma inhibitory activity protein 2 isoform X9

      Conserved Domains (3) summary
      PHA03247
      Location:1114 → 1324
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:671 → 1027
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17036
      Location:31 → 103
      SH3; Src Homology 3 domain superfamily

    11. XM_063261383.1 → XP_063117453.1  melanoma inhibitory activity protein 2 isoform X21

    12. XM_003750164.6 → XP_003750212.1  melanoma inhibitory activity protein 2 isoform X17

      See identical proteins and their annotated locations for XP_003750212.1

      UniProtKB/TrEMBL
      A0A0G2K2J9, D3ZHI1
      Related
      ENSRNOP00000006995.6, ENSRNOT00000006995.10
      Conserved Domains (2) summary
      pfam06409
      Location:393 → 466
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl21478
      Location:165 → 263
      ATP-synt_B; ATP synthase B/B' CF(0)

    13. XM_063261386.1 → XP_063117456.1  melanoma inhibitory activity protein 2 isoform X27

    14. XM_063261387.1 → XP_063117457.1  melanoma inhibitory activity protein 2 isoform X28

    15. XM_063261388.1 → XP_063117458.1  melanoma inhibitory activity protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A0G2KA58

    16. XM_063261389.1 → XP_063117459.1  melanoma inhibitory activity protein 2 isoform X30

    17. XM_017594457.3 → XP_017449946.1  melanoma inhibitory activity protein 2 isoform X24

      UniProtKB/TrEMBL
      D3ZVL1

    18. XM_063261391.1 → XP_063117461.1  melanoma inhibitory activity protein 2 isoform X32

    19. XM_063261392.1 → XP_063117462.1  melanoma inhibitory activity protein 2 isoform X33

      Related
      ENSRNOP00000103258.1, ENSRNOT00000152873.1

    20. XM_063261393.1 → XP_063117463.1  melanoma inhibitory activity protein 2 isoform X34

    21. XM_017594454.3 → XP_017449943.1  melanoma inhibitory activity protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K2J9
      Related
      ENSRNOP00000072272.2, ENSRNOT00000086221.3

    22. XM_063261381.1 → XP_063117451.1  melanoma inhibitory activity protein 2 isoform X14

      Related
      ENSRNOP00000075271.3, ENSRNOT00000077435.3

    23. XM_039111596.2 → XP_038967524.1  melanoma inhibitory activity protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JXM0
      Conserved Domains (2) summary
      PHA03247
      Location:586 → 796
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:149 → 523
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    24. XM_006240128.5 → XP_006240190.1  melanoma inhibitory activity protein 2 isoform X12

      See identical proteins and their annotated locations for XP_006240190.1

      UniProtKB/TrEMBL
      A0A0G2K2J9
      Conserved Domains (2) summary
      pfam06409
      Location:432 → 505
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl21478
      Location:204 → 302
      ATP-synt_B; ATP synthase B/B' CF(0)

    25. XM_063261382.1 → XP_063117452.1  melanoma inhibitory activity protein 2 isoform X18

    26. XM_006240132.5 → XP_006240194.1  melanoma inhibitory activity protein 2 isoform X20

      See identical proteins and their annotated locations for XP_006240194.1

      UniProtKB/TrEMBL
      A0A0G2JXM0
      Conserved Domains (2) summary
      pfam06409
      Location:432 → 505
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl21478
      Location:204 → 302
      ATP-synt_B; ATP synthase B/B' CF(0)

    27. XM_003750165.6 → XP_003750213.2  melanoma inhibitory activity protein 2 isoform X13

      See identical proteins and their annotated locations for XP_003750213.2

      UniProtKB/TrEMBL
      A6HBR5
      Conserved Domains (3) summary
      pfam06409
      Location:408 → 481
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam13949
      Location:212 → 481
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
      cl21478
      Location:180 → 278
      ATP-synt_B; ATP synthase B/B' CF(0)

    28. XM_063261384.1 → XP_063117454.1  melanoma inhibitory activity protein 2 isoform X23

    29. XM_039111599.2 → XP_038967527.1  melanoma inhibitory activity protein 2 isoform X25

      UniProtKB/TrEMBL
      A6HBR5
      Conserved Domains (2) summary
      PHA03247
      Location:553 → 763
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:110 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    30. XM_039111598.2 → XP_038967526.1  melanoma inhibitory activity protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A0G2K2J9
      Conserved Domains (3) summary
      PHA03247
      Location:564 → 774
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:145 → 422
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:16 → 241
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    31. XM_017594455.3 → XP_017449944.1  melanoma inhibitory activity protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K2J9
      Related
      ENSRNOP00000107055.1, ENSRNOT00000152614.1

    32. XM_063261385.1 → XP_063117455.1  melanoma inhibitory activity protein 2 isoform X26

    33. XM_017594456.3 → XP_017449945.1  melanoma inhibitory activity protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A0G2K2J9

    34. XM_063261390.1 → XP_063117460.1  melanoma inhibitory activity protein 2 isoform X31

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106734.1: Suppressed sequence

      Description
      NM_001106734.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: CTAGE5 (GeneID:513132).
    Nucleotide Protein Strain
    Heading Accession and Version

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