Psph phosphoserine phosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psphprovided by RGD
Official Full Name: phosphoserine phosphataseprovided by RGD
Primary source: RGD:1308764
See related: EnsemblRapid:ENSRNOG00000000925 AllianceGenome:RGD:1308764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable L-phosphoserine phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in response to mechanical stimulus; response to nutrient levels; and response to testosterone. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 202.4), Liver (RPKM 72.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32527091..32541182)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26882524..26905084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30514128..30526551)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AU049267 (e-PCR)
- UniSTS:145715

RH129042 (e-PCR)
- UniSTS:212350

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-phosphoserine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-phosphoserine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables L-phosphoserine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-serine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-serine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-serine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoserine phosphatase

Names: O-phosphoserine phosphohydrolase; PSP; PSPase

NP_001009679.1

EC 3.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009679.1 → NP_001009679.1 phosphoserine phosphatase

See identical proteins and their annotated locations for NP_001009679.1

Status: PROVISIONAL

Source sequence(s)

BC088310

UniProtKB/Swiss-Prot

Q5M819

UniProtKB/TrEMBL

A6J0P9

Related

ENSRNOP00000001228.4, ENSRNOT00000001228.9

Conserved Domains (1) summary

cd04309
Location:15 → 216

HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase