Mocs3 molybdenum cofactor synthesis 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mocs3provided by RGD
Official Full Name: molybdenum cofactor synthesis 3provided by RGD
Primary source: RGD:1307044
See related: EnsemblRapid:ENSRNOG00000081351 AllianceGenome:RGD:1307044
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; protein urmylation; and tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (177358639..177360599)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156939763..156941723)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164986421..164988381)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI710081 (e-PCR)
- UniSTS:249885

BE114634 (e-PCR)
- UniSTS:247611

RH143834 (e-PCR)
- UniSTS:233080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables URM1 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables URM1 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase sulfurtransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfurtransferase activity	ISO Inferred from Sequence Orthology more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in molybdopterin cofactor metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein urmylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA thio-modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylyltransferase and sulfurtransferase MOCS3

NP_001101274.1

EC 2.7.7.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107804.1 → NP_001101274.1 adenylyltransferase and sulfurtransferase MOCS3

See identical proteins and their annotated locations for NP_001101274.1

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/TrEMBL

A6JXP5, D4A8L5

Related

ENSRNOP00000102480.1, ENSRNOT00000164099.1

Conserved Domains (3) summary

PRK07411
Location:53 → 458

PRK07411; hypothetical protein; Validated

cd00757
Location:60 → 283

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

cd01526
Location:325 → 458

RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...