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    Cul2 cullin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cul2provided by RGD
    Official Full Name
    cullin 2provided by RGD
    Primary source
    RGD:1310644
    See related
    EnsemblRapid:ENSRNOG00000015292 AllianceGenome:RGD:1310644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within protein catabolic process. Part of VCB complex. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 150.4), Brain (RPKM 115.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cul2 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58864274..58905447, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54169093..54210197, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56952480..56992716, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930596D02 gene like 2 Neighboring gene BMP and activin membrane-bound inhibitor Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene uncharacterized LOC108348578 Neighboring gene cAMP responsive element modulator Neighboring gene marker of proliferation Ki-67, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Ohh M, et al. EMBO Rep, 2002 Feb. PMID 11818338, Free PMC Article
    2. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, et al. Oncogene, 2004 Mar 15. PMID 15021886
    3. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Pause A, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122164, Free PMC Article
    4. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, et al. J Cell Physiol, 2010 Mar. PMID 19950214
    5. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL. Physiology (Bethesda), 2009 Apr. PMID 19364912

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of VCB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399213.1 → NP_001386142.1  cullin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6G8I6, A6K9G9, D4A0H4
      Related
      ENSRNOP00000061765.2, ENSRNOT00000066805.4
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      58864274..58905447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254073.5 → XP_006254135.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_006254135.1

      UniProtKB/TrEMBL
      A0A8I6G8I6, A6K9G9, D4A0H4
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    2. XM_017600628.3 → XP_017456117.1  cullin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8I6, A6K9G9, D4A0H4
      Related
      ENSRNOP00000074075.2, ENSRNOT00000079607.3
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:675 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108417.1: Suppressed sequence

      Description
      NM_001108417.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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