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    Rnf157 ring finger protein 157 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf157provided by RGD
    Official Full Name
    ring finger protein 157provided by RGD
    Primary source
    RGD:1591154
    See related
    EnsemblRapid:ENSRNOG00000049862 AllianceGenome:RGD:1591154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Located in cell body and cytoplasm. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 128.7), Spleen (RPKM 37.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf157 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102070842..102138738, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101571972..101639874, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105291148..105368316, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene putative protein CRIPAK Neighboring gene exocyst complex component 7 Neighboring gene uncharacterized LOC108352160 Neighboring gene forkhead box J1 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, et al. Cell Death Differ, 2015 Apr. PMID 25342469, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin ligase Rnf157
    Names
    RING-type E3 ubiquitin transferase Rnf157
    NP_001406598.1
    XP_038943400.1
    XP_038943402.1
    XP_038943403.1
    XP_038943404.1
    XP_063125930.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419669.1 → NP_001406598.1  E3 ubiquitin ligase Rnf157

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      M0R5D6
      Related
      ENSRNOP00000064600.3, ENSRNOT00000075293.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102070842..102138738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087472.2 → XP_038943400.1  E3 ubiquitin ligase Rnf157 isoform X1

      UniProtKB/Swiss-Prot
      M0R5D6
      Related
      ENSRNOP00000083126.2, ENSRNOT00000103807.2
      Conserved Domains (4) summary
      cd16789
      Location:276 → 316
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl29320
      Location:236 → 330
      KilA-N; KilA-N domain
      pfam03154
      Location:317 → 564
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:477 → 571
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    2. XM_039087474.2 → XP_038943402.1  E3 ubiquitin ligase Rnf157 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVF8
      Related
      ENSRNOP00000066237.4, ENSRNOT00000072230.4
      Conserved Domains (4) summary
      cd16789
      Location:276 → 316
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl29320
      Location:236 → 330
      KilA-N; KilA-N domain
      pfam03154
      Location:317 → 564
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:477 → 571
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    3. XM_039087475.2 → XP_038943403.1  E3 ubiquitin ligase Rnf157 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVF8, M0R9Q8
      Conserved Domains (4) summary
      cd16789
      Location:276 → 316
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl29320
      Location:236 → 330
      KilA-N; KilA-N domain
      pfam03154
      Location:317 → 564
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:477 → 571
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    4. XM_039087476.2 → XP_038943404.1  E3 ubiquitin ligase Rnf157 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVF8
      Related
      ENSRNOP00000104746.1, ENSRNOT00000132354.1
      Conserved Domains (3) summary
      cd16789
      Location:276 → 316
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
      cl29320
      Location:236 → 330
      KilA-N; KilA-N domain
      NF033913
      Location:446 → 571
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    5. XM_063269860.1 → XP_063125930.1  E3 ubiquitin ligase Rnf157 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M0R5D6.2 GenPept UniProtKB/Swiss-Prot:M0R5D6

    Gene LinkOut

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