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    Gzmn granzyme N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691668, updated on 9-Dec-2024

    Summary

    Symbol
    Gzmnprovided by RGD
    Full Name
    granzyme Nprovided by RGD
    Primary source
    RGD:1597226
    See related
    EnsemblRapid:ENSRNOG00000029860 AllianceGenome:RGD:1597226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564878
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space. Orthologous to human GZMB (granzyme B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 35.3) See more
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    Genomic context

    See Gzmn in Genome Data Viewer
    Location:
    15p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33923350..33953255, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29953113..29983018, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (35129622..35160290, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene mast cell protease 10 Neighboring gene cathepsin G Neighboring gene Granzyme F like 1 Neighboring gene granzyme F

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191116.2NP_001178045.1  granzyme N precursor

      See identical proteins and their annotated locations for NP_001178045.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZRW9
      Related
      ENSRNOP00000051075.3, ENSRNOT00000050660.5
      Conserved Domains (1) summary
      cd00190
      Location:21244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33923350..33953255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093674.1XP_038949602.1  granzyme N isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:214437
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_063274666.1XP_063130736.1  granzyme N isoform X5

    3. XM_039093668.1XP_038949596.1  granzyme N isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:238461
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_063274664.1XP_063130734.1  granzyme N isoform X1

    5. XM_039093670.2XP_038949598.1  granzyme N isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:238461
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    6. XM_039093675.2XP_038949603.1  granzyme N isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:214437
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    7. XM_039093666.2XP_038949594.1  granzyme N isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:214437
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    8. XM_039093669.2XP_038949597.1  granzyme N isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:238461
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    9. XM_039093671.2XP_038949599.1  granzyme N isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:238461
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    10. XM_039093676.2XP_038949604.1  granzyme N isoform X3

      Conserved Domains (2) summary
      cd00190
      Location:168391
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:1124
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    11. XM_063274668.1XP_063130738.1  granzyme N isoform X7

    12. XM_063274665.1XP_063130735.1  granzyme N isoform X4

    13. XM_039093672.2XP_038949600.1  granzyme N isoform X6

      UniProtKB/TrEMBL
      D3ZRW9
      Conserved Domains (1) summary
      cd00190
      Location:21244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    14. XM_063274670.1XP_063130740.1  granzyme N isoform X8

    15. XM_063274669.1XP_063130739.1  granzyme N isoform X8

    16. XM_063274667.1XP_063130737.1  granzyme N isoform X6

      UniProtKB/TrEMBL
      D3ZRW9