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    Tsp42En Tetraspanin 42En [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Enprovided by FlyBase
    Official Full Name
    Tetraspanin 42Enprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033135
    Locus tag
    Dmel_CG12839
    See related
    AllianceGenome:FB:FBgn0033135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH02160; CG12839; Dm.Tsp42En; Dmel\CG12839
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42En in Genome Data Viewer
    Location:
    42E7-42E7; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7052747..7054399)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2940252..2941904)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42El Neighboring gene late bloomer Neighboring gene Tetraspanin 42Ep Neighboring gene Tetraspanin 42Eo Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tis11 mediated mRNA decay promotes the reacquisition of Drosophila intestinal stem cell quiescence. McClelland L, et al. Dev Biol, 2017 Jun 1. PMID 28445691, Free PMC Article
    2. Transcriptional Feedback Links Lipid Synthesis to Synaptic Vesicle Pools in Drosophila Photoreceptors. Tsai JW, et al. Neuron, 2019 Feb 20. PMID 30737130, Free PMC Article
    3. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
    4. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    5. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42En
    Names
    CG12839-PA
    CG12839-PB
    Tsp42En-PA
    Tsp42En-PB
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7052747..7054399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273829.1 → NP_001260758.1  tetraspanin 42En, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYY8
      Conserved Domains (2) summary
      cd03127
      Location:96 → 180
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 199
      Tetraspannin; Tetraspanin family

    2. NM_078916.3 → NP_523640.1  tetraspanin 42En, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYY8
      Related
      FBpp0088105
      Conserved Domains (2) summary
      cd03127
      Location:96 → 180
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 199
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYY8 Q7JYY8

    Gene LinkOut

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