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    Msra methionine sulfoxide reductase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msraprovided by RGD
    Official Full Name
    methionine sulfoxide reductase Aprovided by RGD
    Primary source
    RGD:70979
    See related
    EnsemblRapid:ENSRNOG00000012440 AllianceGenome:RGD:70979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in several cellular components, including actin cytoskeleton; midbody; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 499.6), Liver (RPKM 128.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msra in Genome Data Viewer
    Location:
    15p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (42514818..42853278, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (38363459..38677406, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (47488333..47800662, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene serine protease 55 Neighboring gene serine protease 51 Neighboring gene uncharacterized LOC120097017 Neighboring gene protease, serine 52 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene uncharacterized LOC102554489

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Fan H, et al. Antioxid Redox Signal, 2015 Apr 1. PMID 25602783, Free PMC Article
    2. Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging. Petropoulos I, et al. Biochem J, 2001 May 1. PMID 11311146, Free PMC Article
    3. Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Yermolaieva O, et al. Proc Natl Acad Sci U S A, 2004 Feb 3. PMID 14745014, Free PMC Article
    4. Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells. Haenold R, et al. Free Radic Res, 2007 Nov. PMID 17907003
    5. MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death. Prentice HM, et al. Biochem Biophys Res Commun, 2008 Feb 15. PMID 18083115

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Msr play important roles in pancreatic stellate cell function.
      Title: Pancreatic Stellate Cells Serve as a Brake Mechanism on Pancreatic Acinar Cell Calcium Signaling Modulated by Methionine Sulfoxide Reductase Expression.
    2. The study provides the first direct evidence for the biological significance of MsrA in microglia-mediated neuroinflammation.
      Title: Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function.
    3. MsrA probably enhances ATP synthesis by increasing complex IV activity.
      Title: Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.
    4. Specific colorimetric microplate assay for testing MsrA activity quickly, based on the fact that MsrA can catalyze the reduction of methyl sulfoxides and simultaneously oxidize dithiothreitol, whose color can be produced by reacting with Ellman's reagent.
      Title: A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A.
    5. MsrA overexpression in MsrA-depleted cells led to the reduction of increased HO-1 expression, and suppressed nuclear accumulation of Nrf2.
      Title: Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation.
    6. The data indicate that Msr activity is reduced by obesity and may alter oxidative stress signalling of obesity.
      Title: Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue.
    7. The enzymatic properties of MsrA indeed rely on the activation of the catalytic cysteine to the thiolate anion form that is potentially susceptible to oxidation by hydrogen peroxide.
      Title: Impact of hydrogen peroxide on the activity, structure, and conformational stability of the oxidized protein repair enzyme methionine sulfoxide reductase A.
    8. Up-regulation of the expression of Msra could represent a protective response to the increased oxidative stress in the aging myocardium.
      Title: Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts.
    9. This suggests an important role for an MSRA catalytic antioxidant cycle for protection of the cytoplasmic compartment against oxidative damage.
      Title: Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: role of intracellular localization and substrate availability.
    10. Multiple MSRA variants participate in the repair of oxidized proteins in vascular smooth muscle cells mitochondria.
      Title: Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93315

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial peptide methionine sulfoxide reductase
    Names
    PMSR
    peptide Met(O) reductase
    peptide methionine sulfoxide reductase
    peptide-methionine (S)-S-oxide reductase
    protein-methionine-S-oxide reductase
    NP_445759.1
    XP_038949142.1
    XP_038949143.1
    XP_038949144.1
    XP_038949146.1
    XP_063130253.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053307.2 → NP_445759.1  mitochondrial peptide methionine sulfoxide reductase

      See identical proteins and their annotated locations for NP_445759.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087009
      UniProtKB/Swiss-Prot
      A9LAT3, A9LAT4, Q923M1
      UniProtKB/TrEMBL
      A0A8I6A0P8
      Related
      ENSRNOP00000067242.3, ENSRNOT00000072997.5
      Conserved Domains (1) summary
      PRK00058
      Location:20 → 228
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      42514818..42853278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093214.2 → XP_038949142.1  mitochondrial peptide methionine sulfoxide reductase isoform X1

      UniProtKB/Swiss-Prot
      A9LAT3, A9LAT4, Q923M1
      UniProtKB/TrEMBL
      A0A8I6A0P8
      Related
      ENSRNOP00000097940.2, ENSRNOT00000102126.2
      Conserved Domains (1) summary
      PRK00058
      Location:20 → 228
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    2. XM_063274183.1 → XP_063130253.1  mitochondrial peptide methionine sulfoxide reductase isoform X4

    3. XM_039093216.2 → XP_038949144.1  mitochondrial peptide methionine sulfoxide reductase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AN14
      Related
      ENSRNOP00000096051.1, ENSRNOT00000095387.2
      Conserved Domains (1) summary
      PRK00058
      Location:4 → 186
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    4. XM_039093218.2 → XP_038949146.1  mitochondrial peptide methionine sulfoxide reductase isoform X4

      Conserved Domains (1) summary
      cl00366
      Location:2 → 164
      PMSR; Peptide methionine sulfoxide reductase

    5. XM_039093215.1 → XP_038949143.1  mitochondrial peptide methionine sulfoxide reductase isoform X2

      Conserved Domains (1) summary
      PRK00058
      Location:12 → 194
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA

    RNA

    1. XR_010057810.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923M1.1 GenPept UniProtKB/Swiss-Prot:Q923M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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