Cxcl6 C-X-C motif chemokine ligand 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcl6provided by RGD
Official Full Name: C-X-C motif chemokine ligand 6provided by RGD
Primary source: RGD:708540
See related: EnsemblRapid:ENSRNOG00000002843 AllianceGenome:RGD:708540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cxcl5
Summary: Enables chemokine activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of receptor signaling pathway via JAK-STAT; and response to gamma radiation. Located in extracellular space. Used to study colon carcinoma. Biomarker of prostatitis and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to several human genes including CXCL6 (C-X-C motif chemokine ligand 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 12.5), Uterus (RPKM 6.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (17594959..17596417, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (17310790..17312250, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (18860201..18920839, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats.
Title: Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats.
Expression and potential role of CXCL5 in the pathogenesis of intrauterine adhesions.
Title: Expression and potential role of CXCL5 in the pathogenesis of intrauterine adhesions.
CXCL5 Cytokine Is a Major Factor in Platelet-Rich Plasma's Preservation of Erectile Function in Rats After Bilateral Cavernous Nerve Injury.
Title: CXCL5 Cytokine Is a Major Factor in Platelet-Rich Plasma's Preservation of Erectile Function in Rats After Bilateral Cavernous Nerve Injury.
CRH suppressed CXCL5 production in glia via CRHR1 in the hippocampus of male rats.
Title: Corticotropin-Releasing Hormone Suppresses Synapse Formation in the Hippocampus of Male Rats via Inhibition of CXCL5 Secretion by Glia.
up-regulation of spinal CXCL5 and CXCR2 is involved in neuropathic pain after nerve injury, through regulating GSK-3beta activity in rats.
Title: Spinal CXCL5 contributes to nerve injury-induced neuropathic pain via modulating GSK-3β phosphorylation and activity in rats.
Analysis of mitogen-activated protein kinases (MAPK) and glycogen synthase kinase (GSK3) pathways showed that they are involved in mechanisms of neuronal apoptosis in response to the depletion of CXCL5/LIX signaling.
Title: JCV agnoprotein-induced reduction in CXCL5/LIX secretion by oligodendrocytes is associated with activation of apoptotic signaling in neurons.
Data demonstrate that the chemokine CXCL5 is a peripheral mediator of UVB-induced inflammatory pain, likely in humans as well as rats.
Title: CXCL5 mediates UVB irradiation-induced pain.
Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients.
Title: Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients.

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General gene information

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Markers

U27267 (e-PCR)
- UniSTS:179203

U27267 (e-PCR)
- UniSTS:159393

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables chemokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chemokine activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neutrophil mediated killing of gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 5

Names: CXC chemokine LIX; chemokine (C-X-C motif) ligand 5; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); cytokine LIX; small-inducible cytokine B5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022214.2 → NP_071550.2 C-X-C motif chemokine 5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P97885

UniProtKB/TrEMBL

A6KKE7, G3V6C8

Related

ENSRNOP00000003823.1, ENSRNOT00000003823.5

Conserved Domains (1) summary

cd00273
Location:47 → 109

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...