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    Minpp1 multiple inositol-polyphosphate phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Minpp1provided by RGD
    Official Full Name
    multiple inositol-polyphosphate phosphatase 1provided by RGD
    Primary source
    RGD:3089
    See related
    EnsemblRapid:ENSRNOG00000011287 AllianceGenome:RGD:3089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity and inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity. Predicted to be active in endoplasmic reticulum lumen; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 247.8), Kidney (RPKM 218.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Minpp1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239766809..239793023)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230354483..230379730)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251045352..251071045)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene nuclear transport factor 2, pseudogene 1 Neighboring gene cytokine induced apoptosis inhibitor 1, pseudogene 1 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene uncharacterized LOC134485222

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase. Craxton A, et al. Biochem J, 1997 Nov 15. PMID 9359836, Free PMC Article
    2. Hepatic Ins(1,3,4,5)P4 3-phosphatase is compartmentalized inside endoplasmic reticulum. Ali N, et al. J Biol Chem, 1993 Mar 25. PMID 8384201
    3. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. Gimm O, et al. J Clin Endocrinol Metab, 2001 Apr. PMID 11297621
    4. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Cho J, et al. Proc Natl Acad Sci U S A, 2008 Apr 22. PMID 18413611, Free PMC Article
    5. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. Caffrey JJ, et al. FEBS Lett, 1999 Jan 8. PMID 9923613

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phytase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-phytase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol bisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol bisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol pentakisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol trisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol trisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-hexakisphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-hexakisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-hexakisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of intracellular monoatomic cation homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intracellular monoatomic cation homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    multiple inositol polyphosphate phosphatase 1
    Names
    2,3-BPG phosphatase
    2,3-bisphosphoglycerate 3-phosphatase
    inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
    ins(1,3,4,5)P(4) 3-phosphatase
    multiple inositol polyphosphate histidine phosphatase 1
    NP_062136.1
    XP_063143914.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019263.1 → NP_062136.1  multiple inositol polyphosphate phosphatase 1 precursor

      See identical proteins and their annotated locations for NP_062136.1

      Status: VALIDATED

      Source sequence(s)
      AF012714, CO388212, CV120065
      UniProtKB/Swiss-Prot
      O35217
      UniProtKB/TrEMBL
      A6I107, G3V7H2
      Related
      ENSRNOP00000015017.5, ENSRNOT00000015017.8
      Conserved Domains (1) summary
      cd07061
      Location:82 → 429
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      239766809..239793023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287844.1 → XP_063143914.1  multiple inositol polyphosphate phosphatase 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35217.3 GenPept UniProtKB/Swiss-Prot:O35217

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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