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    Plpp2 phospholipid phosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246115, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plpp2provided by RGD
    Official Full Name
    phospholipid phosphatase 2provided by RGD
    Primary source
    RGD:628893
    See related
    EnsemblRapid:ENSRNOG00000000177 AllianceGenome:RGD:628893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppap2c
    Summary
    Predicted to enable ceramide-1-phosphate phosphatase activity; phosphatidate phosphatase activity; and sphingosine-1-phosphate phosphatase activity. Involved in regulation of cell cycle G1/S phase transition. Predicted to be located in caveola; early endosome; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 142.5), Adrenal (RPKM 87.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plpp2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10826534..10834628)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10175918..10184032)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13062168..13070281)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 Neighboring gene MIER family member 2 Neighboring gene uncharacterized LOC120093534 Neighboring gene gonadotropin inducible ovarian transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. Morris KE, et al. J Biol Chem, 2006 Apr 7. PMID 16467304
    2. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Zhang N, et al. Genesis, 2000 Aug. PMID 10992322
    3. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. Roberts R, et al. J Biol Chem, 1998 Aug 21. PMID 9705349
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide-1-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidate phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sphingosine-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase 2
    Names
    PAP-2c
    PAP2-G
    PAP2-gamma
    PAP2c
    lipid phosphate phosphohydrolase 2
    phosphatidate phosphohydrolase type 2c
    phosphatidic acid phosphatase 2c
    phosphatidic acid phosphatase type 2c
    NP_640345.1
    XP_008763377.1
    XP_038934337.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139252.2 → NP_640345.1  phospholipid phosphatase 2

      See identical proteins and their annotated locations for NP_640345.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q8K593
      UniProtKB/TrEMBL
      A0A8I6G688, A6K909
      Related
      ENSRNOP00000000193.1, ENSRNOT00000000193.5
      Conserved Domains (1) summary
      cd03384
      Location:94 → 239
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10826534..10834628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078409.1 → XP_038934337.1  phospholipid phosphatase 2 isoform X2

      Conserved Domains (1) summary
      cl00474
      Location:94 → 172
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    2. XM_008765155.4 → XP_008763377.1  phospholipid phosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_008763377.1

      UniProtKB/TrEMBL
      A6K910
      Conserved Domains (1) summary
      cd03384
      Location:38 → 183
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K593.1 GenPept UniProtKB/Swiss-Prot:Q8K593

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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