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    Xirp1 xin actin-binding repeat containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xirp1provided by RGD
    Official Full Name
    xin actin-binding repeat containing 1provided by RGD
    Primary source
    RGD:1304776
    See related
    EnsemblRapid:ENSRNOG00000037085 AllianceGenome:RGD:1304776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cmya1
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within several processes, including Notch signaling pathway; negative regulation of cell population proliferation; and striated muscle cell development. Predicted to be located in several cellular components, including fascia adherens; focal adhesion; and stress fiber. Orthologous to human XIRP1 (xin actin binding repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 387.1), Heart (RPKM 380.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Xirp1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128625111..128635011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119744778..119757547, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128694809..128712092, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cysteine and serine rich nuclear protein 1 Neighboring gene uncharacterized LOC108351801 Neighboring gene uncharacterized LOC120094294 Neighboring gene uncharacterized LOC134480114 Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene C-C motif chemokine receptor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. Jung-Ching Lin J, et al. J Med Sci, 2005 Oct. PMID 16708114, Free PMC Article
    2. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. Holt I, et al. BMC Mol Cell Biol, 2020 Dec 1. PMID 33261556, Free PMC Article
    3. Xin repeats define a novel actin-binding motif. Pacholsky D, et al. J Cell Sci, 2004 Oct 15. PMID 15454575
    4. Requirement of a novel gene, Xin, in cardiac morphogenesis. Wang DZ, et al. Development, 1999 Mar. PMID 10021346
    5. Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Hawke TJ, et al. Am J Physiol Cell Physiol, 2007 Nov. PMID 17855775

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
      Title: An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast differentiation involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in satellite cell activation involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    xin actin-binding repeat containing 1; xin actin-binding repeat-containing protein 1
    Names
    cardiomyopathy associated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430574.1 → NP_001417503.1  xin actin-binding repeat containing 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5YBK9, A6I3Y7

    2. NM_001430575.1 → NP_001417504.1  xin actin-binding repeat containing 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5YBK9, A6I3Y7

    3. NM_001430576.1 → NP_001417505.1  xin actin-binding repeat containing 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5YBK9, A6I3Y7

    4. NM_001430577.1 → NP_001417506.1  xin actin-binding repeat containing 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ABA9

    5. NM_001430578.1 → NP_001417507.1  xin actin-binding repeat containing 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ABA9

    6. NM_001430579.1 → NP_001417508.1  xin actin-binding repeat containing 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ABA9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128625111..128635011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244155.5 → XP_006244217.1  xin actin-binding repeat-containing protein 1 isoform X2

      Related
      ENSRNOP00000052739.4, ENSRNOT00000055888.5
      Conserved Domains (1) summary
      pfam08043
      Location:549 → 562
      Xin; Xin repeat

    2. XM_006244151.5 → XP_006244213.1  xin actin-binding repeat-containing protein 1 isoform X1

      Related
      ENSRNOP00000091019.1, ENSRNOT00000101246.2
      Conserved Domains (2) summary
      PHA03247
      Location:902 → 1293
      PHA03247; large tegument protein UL36; Provisional
      pfam08043
      Location:510 → 525
      Xin; Xin repeat

    3. XM_008766701.4 → XP_008764923.1  xin actin-binding repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008764923.1

      UniProtKB/TrEMBL
      A0A8I5YBK9, A6I3Y7
      Conserved Domains (2) summary
      PHA03247
      Location:902 → 1293
      PHA03247; large tegument protein UL36; Provisional
      pfam08043
      Location:510 → 525
      Xin; Xin repeat

    4. XM_063266351.1 → XP_063122421.1  xin actin-binding repeat-containing protein 1 isoform X2

    5. XM_017596154.3 → XP_017451643.1  xin actin-binding repeat-containing protein 1 isoform X1

      Related
      ENSRNOP00000077004.1, ENSRNOT00000093872.2
      Conserved Domains (2) summary
      PHA03247
      Location:902 → 1293
      PHA03247; large tegument protein UL36; Provisional
      pfam08043
      Location:510 → 525
      Xin; Xin repeat

    6. XM_063266352.1 → XP_063122422.1  xin actin-binding repeat-containing protein 1 isoform X2

    7. XM_039082728.2 → XP_038938656.1  xin actin-binding repeat-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:902 → 1293
      PHA03247; large tegument protein UL36; Provisional
      pfam08043
      Location:510 → 525
      Xin; Xin repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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