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    Nck2 NCK adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nck2provided by RGD
    Official Full Name
    NCK adaptor protein 2provided by RGD
    Primary source
    RGD:1305965
    See related
    EnsemblRapid:ENSRNOG00000017155 AllianceGenome:RGD:1305965
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including phosphotyrosine residue binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in postsynaptic density. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.4), Lung (RPKM 93.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nck2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53206006..53332417)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (45713979..45840330)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50246767..50373307)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 13 Neighboring gene U2 spliceosomal RNA Neighboring gene golgi phosphoprotein 3-like, pseudogene 1 Neighboring gene ECRG4 augurin precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Guan S, et al. Mol Cell Biol, 2007 Sep. PMID 17591694, Free PMC Article
    2. Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation. Kebache S, et al. J Biol Chem, 2004 Mar 5. PMID 14676213
    3. The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Bladt F, et al. Mol Cell Biol, 2003 Jul. PMID 12808099, Free PMC Article
    4. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. Van Impe K, et al. J Biol Chem, 2003 May 16. PMID 12637565
    5. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Gil D, et al. Cell, 2002 Jun 28. PMID 12110186

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that Nckbeta maintains paxillin stability during neuritogenesis.
      Title: Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immunological synapse formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of PERK-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2
    Names
    non-catalytic region of tyrosine kinase adaptor protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108216.1 → NP_001101686.1  cytoplasmic protein NCK2

      See identical proteins and their annotated locations for NP_001101686.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6INR5, D4A3M8
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      53206006..53332417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244825.5 → XP_006244887.1  cytoplasmic protein NCK2 isoform X1

      See identical proteins and their annotated locations for XP_006244887.1

      UniProtKB/TrEMBL
      A6INR5, D4A3M8
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_063267164.1 → XP_063123234.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      A6INR5, D4A3M8

    3. XM_063267163.1 → XP_063123233.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      A6INR5, D4A3M8

    4. XM_008767035.4 → XP_008765257.1  cytoplasmic protein NCK2 isoform X1

      See identical proteins and their annotated locations for XP_008765257.1

      UniProtKB/TrEMBL
      A6INR5, D4A3M8
      Related
      ENSRNOP00000023029.4, ENSRNOT00000023029.9
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
    Nucleotide Protein Strain
    Heading Accession and Version

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