Strip1 striatin interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Strip1provided by RGD
Official Full Name: striatin interacting protein 1provided by RGD
Primary source: RGD:1564249
See related: EnsemblRapid:ENSRNOG00000018293 AllianceGenome:RGD:1564249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam40a
Summary: Predicted to enable protein kinase binding activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Predicted to be involved in cortical actin cytoskeleton organization; negative regulation of hippo signaling; and regulation of cell morphogenesis. Predicted to be located in nucleus. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in cytosol. Orthologous to human STRIP1 (striatin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 125.9), Brain (RPKM 123.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197936569..197956515, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195248384..195268330, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210393708..210413757, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AW531522 (e-PCR)
- UniSTS:261826

RH137018 (e-PCR)
- UniSTS:219107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: striatin-interacting protein 1

Names: family with sequence similarity 40, member A; protein FAM40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399218.1 → NP_001386147.1 striatin-interacting protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HUU8, G3V8E2

Related

ENSRNOP00000025036.5, ENSRNOT00000025036.10

Conserved Domains (2) summary

pfam07923
Location:66 → 336

N1221; N1221-like protein

pfam11882
Location:460 → 783

DUF3402; Domain of unknown function (DUF3402)