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    BTG2 BTG anti-proliferation factor 2 [ Homo sapiens (human) ]

    Gene ID: 7832, updated on 9-Dec-2024

    Summary

    Official Symbol
    BTG2provided by HGNC
    Official Full Name
    BTG anti-proliferation factor 2provided by HGNC
    Primary source
    HGNC:HGNC:1131
    See related
    Ensembl:ENSG00000159388 MIM:601597; AllianceGenome:HGNC:1131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PC3; APRO1; TIS21
    Summary
    The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 185.2), esophagus (RPKM 183.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See BTG2 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (203305519..203309602)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (202568370..202572442)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203274647..203278730)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:203256086-203257285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2343 Neighboring gene long intergenic non-protein coding RNA 1353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203265487-203265988 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:203268313-203268517 Neighboring gene BTG2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2345 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203275924-203276866 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203276867-203277809 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10869 Neighboring gene RNA, U6 small nuclear 487, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203293504-203294428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2349 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:203297814-203298450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203311519-203312021 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:203315005-203315665 Neighboring gene fibromodulin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of BTG family, member 2 (BTG2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of BTG family, member 2 (BTG2) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126063, MGC126064

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to phorbol 13-acetate 12-myristate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein BTG2
    Names
    B-cell translocation gene 2
    BTG family member 2
    NGF-inducible anti-proliferative protein PC3
    nerve growth factor-inducible anti-proliferative
    pheochromacytoma cell-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046929.1 RefSeqGene

      Range
      4984..9067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006763.3NP_006754.1  protein BTG2

      See identical proteins and their annotated locations for NP_006754.1

      Status: REVIEWED

      Source sequence(s)
      AL513326
      Consensus CDS
      CCDS1437.1
      UniProtKB/Swiss-Prot
      A0A024R986, P78543, Q3KR25, Q5VUT0
      Related
      ENSP00000290551.4, ENST00000290551.5
      Conserved Domains (1) summary
      pfam07742
      Location:9122
      BTG; BTG family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      203305519..203309602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      202568370..202572442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)