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    APA1 bifunctional AP-4-A phosphorylase/ADP sulfurylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APA1
    Official Full Name
    bifunctional AP-4-A phosphorylase/ADP sulfurylase
    Primary source
    SGD:S000000555
    Locus tag
    YCL050C
    See related
    AllianceGenome:SGD:S000000555; FungiDB:YCL050C; VEuPathDB:YCL050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DTP1
    Summary
    Enables bis(5'-nucleosyl)-tetraphosphatase activity and sulfate adenylyltransferase (ADP) activity. Involved in nucleoside catabolic process and nucleotide biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APA1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (37836..38801, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pbn1p Neighboring gene Lre1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physical mapping of the Saccharomyces cerevisiae Ap4A phosphorylase I-encoding gene by the Achilles' cleavage method. Garrison PN, et al. Gene, 1992 Feb 1. PMID 1312500
    2. Synthesis and use of a chromogenic substrate analog for Ap4A catabolic enzymes. Garrison PN, et al. Anal Biochem, 1993 May 1. PMID 7685562
    3. Phosphorolytic cleavage of diadenosine 5',5'''-P1,P4-tetraphosphate. Properties of homogeneous diadenosine 5',5'''-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae. Guranowski A, et al. J Biol Chem, 1985 Mar 25. PMID 2982863
    4. A paradoxical increase of a metabolite upon increased expression of its catabolic enzyme: the case of diadenosine tetraphosphate (Ap4A) and Ap4A phosphorylase I in Saccharomyces cerevisiae. Avila DM, et al. J Bacteriol, 1991 Dec. PMID 1660456, Free PMC Article
    5. Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase. Plateau P, et al. J Bacteriol, 1989 Dec. PMID 2556364, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP:ADP adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ADP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate adenylyltransferase (ADP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate adenylyltransferase (ADP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ADP) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional AP-4-A phosphorylase/ADP sulfurylase
    NP_009880.2
    • AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      37836..38801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178695.1 → NP_009880.2  TPA: bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009880.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW6, P16550
      UniProtKB/TrEMBL
      A6ZTE4, B3LU34, B5VER2, C7GT05, C8Z439, G2W9X7, N1PAN8
      Conserved Domains (1) summary
      COG4360
      Location:2 → 310
      APA2; ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16550.4

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