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    LRE1 Lre1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LRE1
    Official Full Name
    Lre1p
    Primary source
    SGD:S000000556
    Locus tag
    YCL051W
    See related
    AllianceGenome:SGD:S000000556; FungiDB:YCL051W; VEuPathDB:YCL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase inhibitor activity. Involved in fungal-type cell wall organization. Located in cellular bud neck. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LRE1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (35865..37616)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase Neighboring gene Pbn1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Lai MH, et al. Yeast, 1997 Mar 15. PMID 9090049
    2. Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Jansen JM, et al. Curr Biol, 2009 Dec 29. PMID 19962308, Free PMC Article
    3. Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Alonso-Monge R, et al. Mol Microbiol, 2001 Aug. PMID 11532139
    4. Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Versele M, et al. Mol Microbiol, 2001 Sep. PMID 11580836
    5. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance. Bialek-Wyrzykowska U, et al. Mol Microbiol, 2000 Mar. PMID 10760132

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lre1 accumulates at the cell division site in late anaphase and associates with both Mob2 and Cbk1 in vivo and in vitro.
      Title: Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lre1p
    NP_009879.2
    • Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      35865..37616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178696.1 → NP_009879.2  TPA: Lre1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009879.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW5, P25579
      UniProtKB/TrEMBL
      A6ZTE3, B3LU33, C8Z438
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25579.2

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