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    MATALPHA1 transcriptional co-activator mating type protein alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MATALPHA1
    Official Full Name
    transcriptional co-activator mating type protein alpha
    Primary source
    SGD:S000000636
    Locus tag
    YCR040W
    See related
    AllianceGenome:SGD:S000000636; FungiDB:YCR040W; VEuPathDB:YCR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALPHA1
    Summary
    Enables DNA binding activity, bending and transcription coactivator activity. Involved in regulation of mating-type specific transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MATALPHA1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (200442..200969)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene homeodomain mating type protein alpha2 Neighboring gene uncharacterized protein Neighboring gene Taf2p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation affecting sexual agglutinability in MATα locus of Saccharomyces cerevisiae. Doi S, et al. Curr Genet, 1985 Mar. PMID 24173553
    2. Tracing the origin of the fungal α1 domain places its ancestor in the HMG-box superfamily: implication for fungal mating-type evolution. Martin T, et al. PLoS One, 2010 Dec 8. PMID 21170349, Free PMC Article
    3. Control of yeast cell type by the mating type locus: positive regulation of the alpha-specific STE3 gene by the MAT alpha 1 product. Sprague GF Jr, et al. Cell, 1983 Feb. PMID 6337727
    4. A position effect in the control of transcription at yeast mating type loci. Nasmyth KA, et al. Nature, 1981 Jan 22. PMID 6256656
    5. Physical analysis of mating-type loci in Saccharomyces cerevisiae. Nasmyth KA, et al. Cold Spring Harb Symp Quant Biol, 1981. PMID 7021055

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding, bending IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mating-type specific transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mating-type specific transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional co-activator mating type protein alpha
    NP_009869.3
    • Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      200442..200969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178754.1 → NP_009869.3  TPA: transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009869.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV3, P01365, P0CY06, P0CY07
      UniProtKB/TrEMBL
      A6ZTM2, B3LU21, C8Z425, G2WA58
      Conserved Domains (1) summary
      pfam04769
      Location:84 → 143
      MATalpha_HMGbox; Mating-type protein MAT alpha 1 HMG-box
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY06.1
    P0CY07.1

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