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    KNH1 Knh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KNH1
    Official Full Name
    Knh1p
    Primary source
    SGD:S000002207
    Locus tag
    YDL049C
    See related
    AllianceGenome:SGD:S000002207; FungiDB:YDL049C; VEuPathDB:YDL049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in (1->6)-beta-D-glucan biosynthetic process. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KNH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (365068..365874, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Neighboring gene Lhp1p Neighboring gene Stp4p Neighboring gene type 2A-related serine/threonine-protein phosphatase SIT4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9. Dijkgraaf GJ, et al. Yeast, 1996 Jun 15. PMID 8810042
    2. The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids. Mira NP, et al. FEMS Yeast Res, 2009 Mar. PMID 19220866
    3. Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28. Zimmermann C, et al. G3 (Bethesda), 2017 Jun 7. PMID 28428242, Free PMC Article
    4. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Surma MA, et al. Mol Cell, 2013 Aug 22. PMID 23891562, Free PMC Article
    5. Genome-wide study of the adaptation of Saccharomyces cerevisiae to the early stages of wine fermentation. Novo M, et al. PLoS One, 2013. PMID 24040173, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->6)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->6)-beta-D-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in (1->6)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Knh1p
    NP_010234.1
    • Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      365068..365874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180108.1 → NP_010234.1  TPA: Knh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU6, P50112, Q07354
      UniProtKB/TrEMBL
      A6ZXS5, B3LGU8, B5VFL7, C7GW87, C8Z4M0, G2WCB1, N1PAA4
      Conserved Domains (2) summary
      pfam10342
      Location:26 → 129
      GPI-anchored; Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family
      pfam05390
      Location:164 → 264
      KRE9; Yeast cell wall synthesis protein KRE9/KNH1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50112.2

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