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    LUC7 Luc7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LUC7
    Official Full Name
    Luc7p
    Primary source
    SGD:S000002245
    Locus tag
    YDL087C
    See related
    AllianceGenome:SGD:S000002245; FungiDB:YDL087C; VEuPathDB:YDL087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EPE1; EXM2
    Summary
    Enables mRNA binding activity. Involved in mRNA splice site recognition. Located in cytosol and nucleus. Part of U1 snRNP and U2-type prespliceosome. Orthologous to several human genes including LUC7L (LUC7 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LUC7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (300214..300999, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nur1p Neighboring gene FG-nucleoporin ASM4 Neighboring gene carboxymethylenebutenolidase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7. Carrocci TJ, et al. RNA, 2024 Jul 16. PMID 38719745,
    2. The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71. Ester C, et al. BMC Biochem, 2008 Nov 11. PMID 19014439, Free PMC Article
    3. The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human. Puig O, et al. Nucleic Acids Res, 2007. PMID 17726058, Free PMC Article
    4. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. Kofoed M, et al. G3 (Bethesda), 2015 Jul 14. PMID 26175450, Free PMC Article
    5. Adaptive transcription-splicing resynchronization upon losing an essential splicing factor. Chang SL, et al. Nat Ecol Evol, 2018 Nov. PMID 30297747

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7.
      Title: Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7.
    2. Luc7-(31-246) identified as a minimal functional protein. N-terminal 18-amino acid segment of Luc7 plays an important role in U1 snRNP function.
      Title: Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP.
    3. The C-terminal 2 FF domains of Prp40 are dispensable; deletion of additional FF domains is lethal; The first FF domain of Prp40 binds to U1 protein Luc7 and domains 2 and 3 bind to Snu71, another known U1 protein.
      Title: The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splice site recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U1 snRNP IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Luc7p
    NP_010196.1
    • Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      300214..300999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180146.1 → NP_010196.1  TPA: Luc7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRR1, Q07508
      UniProtKB/TrEMBL
      G2WC75, N1PA96
      Conserved Domains (1) summary
      COG5200
      Location:8 → 261
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07508.1

    Gene LinkOut

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