BPL1 biotin--[acetyl-CoA-carboxylase] ligase BPL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BPL1
Official Full Name: biotin--[acetyl-CoA-carboxylase] ligase BPL1
Primary source: SGD:S000002300
Locus tag: YDL141W
See related: AllianceGenome:SGD:S000002300; FungiDB:YDL141W; VEuPathDB:YDL141W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ACC2
Summary: Enables biotin--[biotin carboxyl-carrier protein] ligase activity. Involved in protein modification process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BPL1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (203039..205111)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
Title: Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
presence of 20 monomers organized in five tetramers per asymmetric unit.
Title: Expression, purification, crystallization and preliminary phasing of the heteromerization domain of the tRNA-export and aminoacylation cofactor Arc1p from yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables biotin--[biotin carboxyl-carrier protein] ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables biotin--[biotin carboxyl-carrier protein] ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables biotin--[biotin carboxyl-carrier protein] ligase activity	IEA Inferred from Electronic Annotation more info
enables biotin--[biotin carboxyl-carrier protein] ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein modification process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: biotin--[acetyl-CoA-carboxylase] ligase BPL1

NP_010140.1

EC 6.3.4.10

EC 6.3.4.11

EC 6.3.4.15

EC 6.3.4.9

Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

203039..205111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180201.1 → NP_010140.1 TPA: biotin--[acetyl-CoA-carboxylase] ligase BPL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010140.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRK7, P48445

UniProtKB/TrEMBL

G2WC20, N1P610

Conserved Domains (2) summary

COG0340
Location:388 → 680

BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]

pfam09825
Location:2 → 374

BPL_N; Biotin-protein ligase, N terminal