ATG9 autophagy protein ATG9 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG9
Official Full Name: autophagy protein ATG9
Primary source: SGD:S000002308
Locus tag: YDL149W
See related: AllianceGenome:SGD:S000002308; FungiDB:YDL149W; VEuPathDB:YDL149W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APG9; AUT9; CVT6; CVT7
Summary: Enables phospholipid scramblase activity. Involved in cytoplasm to vacuole targeting by the Cvt pathway; macroautophagy; and phospholipid translocation. Located in several cellular components, including cytoplasmic vesicle membrane; phagophore; and phagophore assembly site. Orthologous to human ATG9A (autophagy related 9A) and ATG9B (autophagy related 9B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATG9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (184925..187918)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Atg1 complex, Atg9, and Vac8 recruit PI3K complex I to the pre-autophagosomal structure.
Title: The Atg1 complex, Atg9, and Vac8 recruit PI3K complex I to the pre-autophagosomal structure.
The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation.
Title: The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation.
Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway.
Title: Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway.
Atg9-centered multi-omics integration reveals new autophagy regulators in Saccharomyces cerevisiae.
Title: Atg9-centered multi-omics integration reveals new autophagy regulators in Saccharomyces cerevisiae.
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.
Title: Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.
Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation.
Title: Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation.
Autophagy regulator Atg9 is degraded by the proteasome.
Title: Autophagy regulator Atg9 is degraded by the proteasome.
Atg9 vesicle trafficking is perturbed in exocyst complex temperature-sensitive mutants.
Title: Exocyst Subcomplex Functions in Autophagosome Biogenesis by Regulating Atg9 Trafficking.
Data show that activated autophagy protein ATG11 (Atg11) dimerizes and tethers autophagy protein ATG9 (Atg9) vesicles.
Title: Atg11 tethers Atg9 vesicles to initiate selective autophagy.
Septins also colocalized with autophagosomes, where they physically interacted with the autophagy proteins Atg8 and Atg9. When autophagosome degradation was blocked in septin-mutant cells, fewer autophagic structures accumulated, and an autophagy mutant defective in early stages of autophagosome biogenesis (atg1Delta), displayed decreased septin localization to the pre-autophagosomal structure.
Title: Septins are involved at the early stages of macroautophagy in S. cerevisiae.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phospholipid scramblase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in phagophore	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: autophagy protein ATG9

NP_010132.1

Lipid scramblase that mediates autophagosomal membrane expansion; translocates phospholipids between outer and inner leaflets of liposomes; transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between phagophore assembly site (PAS) and other cytosolic punctate structures

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

184925..187918

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180209.1 → NP_010132.1 TPA: autophagy protein ATG9 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010132.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZXH8, D6VRJ9, Q12142

UniProtKB/TrEMBL

G2WC12, N1PAM5

Conserved Domains (1) summary

pfam04109
Location:295 → 776

APG9; Autophagy protein Apg9